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@ARTICLE{Kppers:1029133,
      author       = {Küppers, Vincent and Bi, Hanwen and Nicolaisen-Sobesky,
                      Eliana and Hoffstaedter, Felix and Yeo, B. T. Thomas and
                      Drzezga, Alexander and Eickhoff, Simon B. and Tahmasian,
                      Masoud},
      title        = {{L}ower motor performance is linked with poor sleep
                      quality, depressive symptoms, and grey matter volume
                      alterations},
      reportid     = {FZJ-2024-04989},
      year         = {2024},
      abstract     = {Motor performance (MP) is essential for functional
                      independence and well-being, particularly in later life.
                      However, the relationship between behavioural aspects such
                      as sleep quality and depressive symptoms, which contribute
                      to MP, and the underlying structural brain substrates of
                      their interplay remains unclear. This study used three
                      population-based cohorts of younger and older adults
                      (n=1,950) from the Human Connectome Project-Young Adult
                      (HCP-YA), HCP-Aging (HCP-A), and enhanced Nathan Kline
                      Institute-Rockland sample (eNKI-RS). Several canonical
                      correlation analyses were computed within a machine learning
                      framework to assess the associations between each of the
                      three domains (sleep quality, depressive symptoms, grey
                      matter volume (GMV)) and MP. The HCP-YA analyses showed
                      progressively stronger associations between MP and each
                      domain: depressive symptoms (unexpectedly positive, r=0.13,
                      SD=0.06), sleep quality (r=0.17, SD=0.05), and GMV (r=0.19,
                      SD=0.06). Combining sleep and depressive symptoms
                      significantly improved the canonical correlations (r=0.25,
                      SD=0.05), while the addition of GMV exhibited no further
                      increase (r=0.23, SD=0.06). In young adults, better sleep
                      quality, mild depressive symptoms, and GMV of several brain
                      regions were associated with better MP. This was
                      conceptually replicated in young adults from the eNKI-RS
                      cohort. In HCP-Aging, better sleep quality, fewer depressive
                      symptoms, and increased GMV were associated with MP. Robust
                      multivariate associations were observed between sleep
                      quality, depressive symptoms and GMV with MP, as well as
                      age-related variations in these factors. Future studies
                      should further explore these associations and consider
                      interventions targeting sleep and mental health to test the
                      potential effects on MP across the lifespan.Keywords: Brain
                      structure; Canonical Correlation Analysis; Depressive
                      Symptoms; Mental Health; Motor Performance Behaviour; Sleep
                      Quality.},
      cin          = {INM-7 / INM-2},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525) / 5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252 /
                      G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.06.07.597666},
      url          = {https://juser.fz-juelich.de/record/1029133},
}