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@ARTICLE{Hettwer:1029553,
      author       = {Hettwer, Meike D. and Dorfschmidt, Lena and Puhlmann, Lara
                      M. C. and Jacob, Linda M. and Paquola, Casey and Bethlehem,
                      Richard A. I. and Bullmore, Edward T. and Eickhoff, Simon B.
                      and Valk, Sofie L.},
      title        = {{L}ongitudinal variation in resilient psychosocial
                      functioning is associated with ongoing cortical myelination
                      and functional reorganization during adolescence},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2024-05165},
      pages        = {6283},
      year         = {2024},
      abstract     = {Adolescence is a period of dynamic brain remodeling and
                      susceptibility to psychiatric risk factors, mediated by the
                      protracted consolidation of association cortices. Here, we
                      investigated whether longitudinal variation in adolescents'
                      resilience to psychosocial stressors during this vulnerable
                      period is associated with ongoing myeloarchitectural
                      maturation and consolidation of functional networks. We used
                      repeated myelin-sensitive Magnetic Transfer (MT) and
                      resting-state functional neuroimaging (n = 141), and
                      captured adversity exposure by adverse life events,
                      dysfunctional family settings, and socio-economic status at
                      two timepoints, one to two years apart. Development toward
                      more resilient psychosocial functioning was associated with
                      increasing myelination in the anterolateral prefrontal
                      cortex, which showed stabilized functional connectivity.
                      Studying depth-specific intracortical MT profiles and the
                      cortex-wide synchronization of myeloarchitectural
                      maturation, we further observed wide-spread
                      myeloarchitectural reconfiguration of association cortices
                      paralleled by attenuated functional reorganization with
                      increasingly resilient outcomes. Together,
                      resilient/susceptible psychosocial functioning showed
                      considerable intra-individual change associated with
                      multi-modal cortical refinement processes at the local and
                      system-level.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39075054},
      UT           = {WOS:001280592000018},
      doi          = {10.1038/s41467-024-50292-2},
      url          = {https://juser.fz-juelich.de/record/1029553},
}