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@ARTICLE{Pieri:1029557,
      author       = {Pieri, Alice and Beleggia, Romina and Gioia, Tania and
                      Tong, Hao and Di Vittori, Valerio and Frascarelli, Giulia
                      and Bitocchi, Elena and Nanni, Laura and Bellucci, Elisa and
                      Fiorani, Fabio and Pecchioni, Nicola and Marzario, Stefania
                      and De Quattro, Concetta and Limongi, Antonina Rita and De
                      Vita, Pasquale and Rossato, Marzia and Schurr, Ulrich and
                      David, Jacques L and Nikoloski, Zoran and Papa, Roberto},
      title        = {{T}ranscriptomic response to nitrogen availability reveals
                      signatures of adaptive plasticity during tetraploid wheat
                      domestication},
      journal      = {The plant cell},
      volume       = {36},
      number       = {9},
      issn         = {1040-4651},
      address      = {Rockville, Md.},
      publisher    = {Soc.},
      reportid     = {FZJ-2024-05167},
      pages        = {3809-3823},
      year         = {2024},
      abstract     = {The domestication of crops, coupled with agroecosystem
                      development, is associated with major environmental changes
                      and provides an ideal model of phenotypic plasticity. Here,
                      we examined 32 genotypes of three tetraploid wheat (Triticum
                      turgidum L.) subspecies, wild emmer, emmer, and durum wheat,
                      which are representative of the key stages in the
                      domestication of tetraploid wheat. We developed a pipeline
                      that integrates RNA-Seq data and population genomics to
                      assess gene expression plasticity and identify selection
                      signatures under diverse nitrogen availability conditions.
                      Our analysis revealed differing gene expression responses to
                      nitrogen availability across primary (wild emmer to emmer)
                      and secondary (emmer to durum wheat) domestication. Notably,
                      nitrogen triggered the expression of twice as many genes in
                      durum wheat compared to that in emmer and wild emmer. Unique
                      selection signatures were identified at each stage: primary
                      domestication mainly influenced genes related to biotic
                      interactions, whereas secondary domestication affected genes
                      related to amino acid metabolism, in particular lysine.
                      Selection signatures were found in differentially expressed
                      genes (DEGs), notably those associated with nitrogen
                      metabolism, such as the gene encoding glutamate
                      dehydrogenase (GDH). Overall, our study highlights the
                      pivotal role of nitrogen availability in the domestication
                      and adaptive responses of a major food crop, with varying
                      effects across different traits and growth conditions.},
      cin          = {IBG-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39056474},
      UT           = {WOS:001280850900001},
      doi          = {10.1093/plcell/koae202},
      url          = {https://juser.fz-juelich.de/record/1029557},
}