001030471 001__ 1030471
001030471 005__ 20250203133201.0
001030471 0247_ $$2doi$$a10.1002/1873-3468.14997
001030471 0247_ $$2ISSN$$a0014-5793
001030471 0247_ $$2ISSN$$a1873-3468
001030471 0247_ $$2datacite_doi$$a10.34734/FZJ-2024-05317
001030471 0247_ $$2pmid$$a39160442
001030471 0247_ $$2WOS$$aWOS:001285593800001
001030471 037__ $$aFZJ-2024-05317
001030471 041__ $$aEnglish
001030471 082__ $$a610
001030471 1001_ $$0P:(DE-Juel1)181095$$aÜffing, Alina$$b0
001030471 245__ $$aGABARAP interacts with EGFR — supporting the unique role of this hAtg8 protein during receptor trafficking
001030471 260__ $$aChichester$$bWiley$$c2024
001030471 3367_ $$2DRIVER$$aarticle
001030471 3367_ $$2DataCite$$aOutput Types/Journal article
001030471 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1734176659_20063
001030471 3367_ $$2BibTeX$$aARTICLE
001030471 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001030471 3367_ $$00$$2EndNote$$aJournal Article
001030471 520__ $$aThe human Atg8 family member GABARAP is involved in numerous autophagy-related and -unrelated processes. We recently observed that specifically the deficiency of GABARAP enhances epidermal growth factor receptor (EGFR) degradation upon ligand stimulation. Here, we report on two putative LC3-interacting regions (LIRs) within EGFR, the first of which (LIR1) is selected as a GABARAP binding site in silico. Indeed, in vitro interaction studies reveal preferential binding of LIR1 to GABARAP and GABARAPL1. Our X-ray data demonstrate interaction of core LIR1 residues FLPV with both hydrophobic pockets of GABARAP suggesting canonical binding. Although LIR1 occupies the LIR docking site, GABARAP Y49 and L50 appear dispensable in this case. Our data support the hypothesis that GABARAP affects the fate of EGFR at least in part through direct binding.
001030471 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001030471 536__ $$0G:(GEPRIS)289554527$$aSFB 1208 B02 - Spezifische Rollen von Atg8s im Vesikeltransport (B02) (289554527)$$c289554527$$x1
001030471 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001030471 7001_ $$0P:(DE-Juel1)131988$$aWeiergräber, Oliver H.$$b1$$eCorresponding author
001030471 7001_ $$0P:(DE-Juel1)132019$$aSchwarten, Melanie$$b2
001030471 7001_ $$0P:(DE-Juel1)132003$$aHoffmann, Silke$$b3$$eCorresponding author
001030471 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b4
001030471 773__ $$0PERI:(DE-600)1460391-3$$a10.1002/1873-3468.14997$$gp. 1873-3468.14997$$nx$$ponline ahead of print$$tFEBS letters$$vx$$x0014-5793$$y2024
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/FEBS%20Letters%20-%202024%20-%20%C3%9Cffing%20-%20GABARAP%20interacts%20with%20EGFR%20supporting%20the%20unique%20role%20of%20this%20hAtg8%20protein%20during.pdf$$yOpenAccess
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/Ueffing_et_al_GABARAP%20interacts%20with%20EGFR_FEBS%20Letters.pdf$$yOpenAccess
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/Ueffing_et_al_GABARAP%20interacts%20with%20EGFR_FEBS%20Letters.gif?subformat=icon$$xicon$$yOpenAccess
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/Ueffing_et_al_GABARAP%20interacts%20with%20EGFR_FEBS%20Letters.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/Ueffing_et_al_GABARAP%20interacts%20with%20EGFR_FEBS%20Letters.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
001030471 8564_ $$uhttps://juser.fz-juelich.de/record/1030471/files/Ueffing_et_al_GABARAP%20interacts%20with%20EGFR_FEBS%20Letters.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
001030471 909CO $$ooai:juser.fz-juelich.de:1030471$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001030471 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)181095$$aForschungszentrum Jülich$$b0$$kFZJ
001030471 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131988$$aForschungszentrum Jülich$$b1$$kFZJ
001030471 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132019$$aForschungszentrum Jülich$$b2$$kFZJ
001030471 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132003$$aForschungszentrum Jülich$$b3$$kFZJ
001030471 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132029$$aForschungszentrum Jülich$$b4$$kFZJ
001030471 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001030471 9141_ $$y2024
001030471 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-23
001030471 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-23
001030471 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-08-23$$wger
001030471 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-23
001030471 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001030471 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
001030471 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFEBS LETT : 2022$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-19
001030471 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-19
001030471 920__ $$lyes
001030471 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
001030471 980__ $$ajournal
001030471 980__ $$aVDB
001030471 980__ $$aUNRESTRICTED
001030471 980__ $$aI:(DE-Juel1)IBI-7-20200312
001030471 9801_ $$aFullTexts