% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{ffing:1030471,
      author       = {Üffing, Alina and Weiergräber, Oliver H. and Schwarten,
                      Melanie and Hoffmann, Silke and Willbold, Dieter},
      title        = {{GABARAP} interacts with {EGFR} — supporting the unique
                      role of this h{A}tg8 protein during receptor trafficking},
      journal      = {FEBS letters},
      volume       = {x},
      number       = {x},
      issn         = {0014-5793},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {FZJ-2024-05317},
      pages        = {online ahead of print},
      year         = {2024},
      abstract     = {The human Atg8 family member GABARAP is involved in
                      numerous autophagy-related and -unrelated processes. We
                      recently observed that specifically the deficiency of
                      GABARAP enhances epidermal growth factor receptor (EGFR)
                      degradation upon ligand stimulation. Here, we report on two
                      putative LC3-interacting regions (LIRs) within EGFR, the
                      first of which (LIR1) is selected as a GABARAP binding site
                      in silico. Indeed, in vitro interaction studies reveal
                      preferential binding of LIR1 to GABARAP and GABARAPL1. Our
                      X-ray data demonstrate interaction of core LIR1 residues
                      FLPV with both hydrophobic pockets of GABARAP suggesting
                      canonical binding. Although LIR1 occupies the LIR docking
                      site, GABARAP Y49 and L50 appear dispensable in this case.
                      Our data support the hypothesis that GABARAP affects the
                      fate of EGFR at least in part through direct binding.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / SFB 1208 B02 - Spezifische Rollen von Atg8s im
                      Vesikeltransport (B02) (289554527)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)289554527},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39160442},
      UT           = {WOS:001285593800001},
      doi          = {10.1002/1873-3468.14997},
      url          = {https://juser.fz-juelich.de/record/1030471},
}