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001030754 1001_ $$0P:(DE-Juel1)191294$$aSerio, Bianca$$b0$$eCorresponding author
001030754 245__ $$aSex differences in functional cortical organization reflect differences in network topology rather than cortical morphometry
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001030754 520__ $$aDifferences in brain size between the sexes are consistently reported. However, the consequences of this anatomical difference on sex differences in intrinsic brain function remain unclear. In the current study, we investigate whether sex differences in intrinsic cortical functional organization may be associated with differences in cortical morphometry, namely different measures of brain size, microstructure, and the geodesic distance of connectivity profiles. For this, we compute a low dimensional representation of functional cortical organization, the sensory-association axis, and identify widespread sex differences. Contrary to our expectations, sex differences in functional organization do not appear to be systematically associated with differences in total surface area, microstructural organization, or geodesic distance, despite these morphometric properties being per se associated with functional organization and differing between sexes. Instead, functional sex differences in the sensory-association axis are associated with differences in functional connectivity profiles and network topology. Collectively, our findings suggest that sex differences in functional cortical organization extend beyond sex differences in cortical morphometry.
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001030754 7001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D.$$b1
001030754 7001_ $$0P:(DE-Juel1)176497$$aWiersch, Lisa$$b2
001030754 7001_ $$0P:(DE-HGF)0$$aBignardi, Giacomo$$b3
001030754 7001_ $$0P:(DE-HGF)0$$aSacher, Julia$$b4
001030754 7001_ $$0P:(DE-Juel1)172811$$aWeis, Susanne$$b5
001030754 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b6$$ufzj
001030754 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b7$$eCorresponding author
001030754 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-51942-1$$gVol. 15, no. 1, p. 7714$$n1$$p7714$$tNature Communications$$v15$$x2041-1723$$y2024
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