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@ARTICLE{Paul:1030852,
      author       = {Paul, Theresa and Cieslak, Matthew and Hensel, Lukas and
                      Wiemer, Valerie M. and Tscherpel, Caroline and Grefkes,
                      Christian and Grafton, Scott T. and Fink, Gereon R. and
                      Volz, Lukas J.},
      title        = {{C}orticospinal premotor fibers facilitate complex motor
                      control after stroke},
      journal      = {Annals of Clinical and Translational Neurology},
      volume       = {11},
      number       = {9},
      issn         = {2328-9503},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2024-05461},
      pages        = {2439-2449},
      year         = {2024},
      abstract     = {Objective: The corticospinal tract (CST) is considered the
                      most important motor output pathway comprising fibers from
                      the primary motor cortex (M1) and various premotor areas.
                      Damage to its descending fibers after stroke commonly leads
                      to motor impairment. While premotor areas are thought to
                      critically support motor recovery after stroke, the
                      functional role of their corticospinal output for different
                      aspects of post-stroke motor control remains poorly
                      understood.Methods: We assessed the differential role of CST
                      fibers originating from premotor areas and M1 in the control
                      of basal (single-joint muscle synergies and strength) and
                      complex motor control (involving inter-joint coordination
                      and visuomotor integration) using a novel diffusion imaging
                      approach in chronic stroke patients.Results: While M1
                      sub-tract anisotropy was positively correlated with basal
                      and complex motor skills, anisotropy of PMd, PMv, and SMA
                      sub-tracts was exclusively associated with complex motor
                      tasks. Interestingly, patients featuring persistent motor
                      deficits showed an additional positive association between
                      premotor sub-tract integrity and basal motor
                      control.Interpretation: While descending M1 output seems to
                      be a prerequisite for any form of upper limb movements,
                      complex motor skills critically depend on output from
                      premotor areas after stroke. The additional involvement of
                      premotor tracts in basal motor control in patients with
                      persistent deficits emphasizes their compensatory capacity
                      in post-stroke motor control. In summary, our findings
                      highlight the pivotal role of descending corticospinal
                      output from premotor areas for motor control after stroke,
                      which thus serve as prime candidates for future
                      interventions to amplify motor recovery.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39073030},
      UT           = {WOS:001278711400001},
      doi          = {10.1002/acn3.52159},
      url          = {https://juser.fz-juelich.de/record/1030852},
}