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@ARTICLE{Schild:1030855,
      author       = {Schild, Ann-Katrin and Scharfenberg, Daniel and Regorius,
                      Anton and Klein, Kim and Kirchner, Lukas and Yasemin,
                      Goereci and Lülling, Joachim and Meiberth, Dix and
                      Schweitzer, Finja and Fink, Gereon Rudolf and Jessen, Frank
                      and Franke, Christiana and Onur, Oezguer A. and Jost,
                      Stefanie Theresa and Warnke, Clemens and Maier, Franziska},
      title        = {{S}ix-month follow-up of multidomain cognitive impairment
                      in non-hospitalized individuals with post-{COVID}-19
                      syndrome},
      journal      = {Archiv für Psychiatrie und Nervenkrankheiten},
      volume       = {274},
      number       = {8},
      issn         = {1433-8491},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2024-05464},
      pages        = {1945 - 1957},
      year         = {2024},
      note         = {The research leading to these results received funding from
                      the German Research Foundation under Grant No (PR 1274/8-1;
                      FR 4479/1-1; WA4101/2-1) supporting CF (FR 4479/1-1) and CW
                      (WA 410/2-1).Open Access funding enabled and organized by
                      Projekt DEAL.},
      abstract     = {Some people infected with SARS-CoV-2 report persisting
                      symptoms following acute infection. If these persist for
                      over three months, they are classified as post-COVID-19
                      syndrome (PCS). Although PCS is frequently reported,
                      detailed longitudinal neuropsychological characterization
                      remains scarce. We aimed to describe the trajectory of
                      cognitive and neuropsychiatric PCS symptoms. 42 individuals
                      with persisting cognitive deficits after asymptomatic to
                      mild/moderate acute COVID-19 at study inclusion received
                      neuropsychological assessment at baseline (BL) and follow-up
                      (FU; six months after BL). Assessments included
                      comprehensive testing of five neurocognitive domains, two
                      cognitive screening tests, and questionnaires on depression,
                      anxiety, sleep, fatigue, and health-related quality of life.
                      Results showed high rates of subjective cognitive complaints
                      at BL and FU $(95.2\%$ versus $88.1\%)$ without significant
                      change over time. However, objectively measured
                      neurocognitive disorder (NCD) decreased $(61.9\%$ versus
                      $42.9\%).$ All cognitive domains were affected, yet most
                      deficits were found in learning and memory, followed by
                      executive functions, complex attention, language, and
                      perceptual motor functions. In individuals with NCD, the
                      first three domains mentioned improved significantly over
                      time, while the last two domains remained unchanged.
                      Cognitive screening tests did not prove valuable in
                      detecting impairment. Neuropsychiatric symptoms remained
                      constant except for quality of life, which improved. This
                      study emphasizes the importance of comprehensive
                      neuropsychological assessment in longitudinal research and
                      provides valuable insights into the trajectory of long-term
                      neuropsychological impairments in PCS. While cognitive
                      performance significantly improved in many domains,
                      neuropsychiatric symptoms remained unchanged.Keywords:
                      Cognitive deficits; Long COVID; Neurocognitive disorder;
                      Neuropsychology; SARS-CoV-2; Subjective complaints.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39048833},
      UT           = {WOS:001275409200001},
      doi          = {10.1007/s00406-024-01863-3},
      url          = {https://juser.fz-juelich.de/record/1030855},
}