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@ARTICLE{Lotter:1030870,
      author       = {Lotter, Leon and Nehls, Susanne and Losse, Elena and
                      Dukart, Jürgen and Chechko, Natalya},
      title        = {{T}emporal dissociation between local and global functional
                      adaptations of the maternal brain to childbirth: a
                      longitudinal assessment},
      journal      = {Neuropsychopharmacology},
      volume       = {49},
      issn         = {0893-133X},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2024-05479},
      pages        = {1809-1818},
      year         = {2024},
      note         = {FundingThe study was funded by the Rotation Program
                      (2015–2017) of the Medical Faculty, University Hospital
                      RWTH Aachen, and the Deutsche Forschungsgemeinschaft (DFG;
                      410314797 and 512021469). Open Access funding enabled and
                      organized by Projekt DEAL.},
      abstract     = {The maternal brain undergoes significant reorganization
                      during birth and the postpartum period. However, the
                      temporal dynamics of these changes remain unclear. Using
                      resting-state functional magnetic resonance imaging, we
                      report on local and global brain function alterations in 75
                      mothers in their first postpartum week, compared to 23
                      nulliparous women. In a subsample followed longitudinally
                      for the next six months, we observed a temporal and spatial
                      dissociation between changes observed at baseline (cluster
                      mass permutation: pFWE < 0.05). Local activity and
                      connectivity changes in widespread neocortical regions
                      persisted throughout the studied time period (ANCOVAs vs.
                      controls: pFDR < 0.05), with preliminary evidence linking
                      these alterations to behavioral and psychological
                      adaptations (interaction effect with postpartum time:
                      uncorrected p < 0.05). In contrast, the initially reduced
                      whole-brain connectivity of putamen-centered subcortical
                      areas returned to control levels within six to nine weeks
                      postpartum (linear and quadratic mixed linear models: pFDR <
                      0.05). The whole-brain spatial colocalization with hormone
                      receptor distributions (Spearman correlations: pFDR < 0.05)
                      and preliminary blood hormone associations (interaction
                      effect with postpartum time: uncorrected p < 0.05) suggested
                      that the postpartum restoration of progesterone levels may
                      underlie this rapid normalization. These observations
                      enhance our understanding of healthy maternal brain
                      function, contributing to the identification of potential
                      markers for pathological postpartum adaptation processes,
                      which in turn could underlie postpartum psychiatric
                      disorders.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38769432},
      UT           = {WOS:001228387400001},
      doi          = {10.1038/s41386-024-01880-9},
      url          = {https://juser.fz-juelich.de/record/1030870},
}