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@ARTICLE{Endepols:1030872,
      author       = {Endepols, Heike and Apetz, Nadine and Vieth, Lukas and
                      Lesser, Christoph and Schulte-Holtey, Léon and Neumaier,
                      Bernd and Drzezga, Alexander},
      title        = {{C}erebellar {M}etabolic {C}onnectivity during {T}readmill
                      {W}alking before and after {U}nilateral {D}opamine
                      {D}epletion in {R}ats},
      journal      = {International journal of molecular sciences},
      volume       = {25},
      number       = {16},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2024-05481},
      pages        = {8617},
      year         = {2024},
      abstract     = {Compensatory changes in brain connectivity keep motor
                      symptoms mild in prodromalParkinson’s disease. Studying
                      compensation in patients is hampered by the steady
                      progression ofthe disease and a lack of individual baseline
                      controls. Furthermore, combining fMRI with walkingis
                      intricate. We therefore used a seed-based metabolic
                      connectivity analysis based on
                      2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake in a
                      unilateral 6-OHDA rat model. At baseline and in thechronic
                      phase 6–7 months after lesion, rats received an
                      intraperitoneal injection of [18F]FDG andspent 50 min
                      walking on a horizontal treadmill, followed by a brain
                      PET-scan under anesthesia. Highactivity was found in the
                      cerebellar anterior vermis in both conditions. At baseline,
                      the anterior vermisshowed hardly any stable connections to
                      the rest of the brain. The (future) ipsilesional
                      cerebellarhemisphere was not particularly active during
                      walking but was extensively connected to many brainareas.
                      After unilateral dopamine depletion, rats still walked
                      normally without obvious impairments.The ipsilesional
                      cerebellar hemisphere increased its activity, but narrowed
                      its connections down tothe vestibulocerebellum, probably
                      aiding lateral stability. The anterior vermis established a
                      networkinvolving the motor cortex, hippocampus and thalamus.
                      Adding those regions to the vermis networkof (previously)
                      automatic control of locomotion suggests that after
                      unilateral dopamine depletionconsiderable conscious and
                      cognitive effort has to be provided to achieve stable
                      walking.},
      cin          = {INM-5 / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5252 - Brain Dysfunction
                      and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39201305},
      UT           = {WOS:001305656000001},
      doi          = {10.3390/ijms25168617},
      url          = {https://juser.fz-juelich.de/record/1030872},
}