Home > Publications database > Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats > print

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024 7 _ |a 10.3390/ijms25168617
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024 7 _ |a 10.34734/FZJ-2024-05481
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100 1 _ |a Endepols, Heike
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245 _ _ |a Cerebellar Metabolic Connectivity during Treadmill Walking before and after Unilateral Dopamine Depletion in Rats
260 _ _ |a Basel
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|b Molecular Diversity Preservation International
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520 _ _ |a Compensatory changes in brain connectivity keep motor symptoms mild in prodromalParkinson’s disease. Studying compensation in patients is hampered by the steady progression ofthe disease and a lack of individual baseline controls. Furthermore, combining fMRI with walkingis intricate. We therefore used a seed-based metabolic connectivity analysis based on 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake in a unilateral 6-OHDA rat model. At baseline and in thechronic phase 6–7 months after lesion, rats received an intraperitoneal injection of [18F]FDG andspent 50 min walking on a horizontal treadmill, followed by a brain PET-scan under anesthesia. Highactivity was found in the cerebellar anterior vermis in both conditions. At baseline, the anterior vermisshowed hardly any stable connections to the rest of the brain. The (future) ipsilesional cerebellarhemisphere was not particularly active during walking but was extensively connected to many brainareas. After unilateral dopamine depletion, rats still walked normally without obvious impairments.The ipsilesional cerebellar hemisphere increased its activity, but narrowed its connections down tothe vestibulocerebellum, probably aiding lateral stability. The anterior vermis established a networkinvolving the motor cortex, hippocampus and thalamus. Adding those regions to the vermis networkof (previously) automatic control of locomotion suggests that after unilateral dopamine depletionconsiderable conscious and cognitive effort has to be provided to achieve stable walking.
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700 1 _ |a Vieth, Lukas
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700 1 _ |a Lesser, Christoph
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