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@ARTICLE{Georgiadis:1030921,
      author       = {Georgiadis, Foivos and Larivière, Sara and Glahn, David
                      and Hong, L. Elliot and Kochunov, Peter and Mowry, Bryan and
                      Loughland, Carmel and Pantelis, Christos and Henskens, Frans
                      A. and Green, Melissa J. and Cairns, Murray J. and Michie,
                      Patricia T. and Rasser, Paul E. and Catts, Stanley and
                      Tooney, Paul and Scott, Rodney J. and Schall, Ulrich and
                      Carr, Vaughan and Quidé, Yann and Krug, Axel and Stein,
                      Frederike and Nenadić, Igor and Brosch, Katharina and
                      Kircher, Tilo and Gur, Raquel and Gur, Ruben and
                      Satterthwaite, Theodore D. and Karuk, Andriana and Pomarol-
                      Clotet, Edith and Radua, Joaquim and Fuentes-Claramonte,
                      Paola and Salvador, Raymond and Spalletta, Gianfranco and
                      Voineskos, Aristotle and Sim, Kang and Crespo-Facorro,
                      Benedicto and Tordesillas Gutiérrez, Diana and Ehrlich,
                      Stefan and Crossley, Nicolas and Grotegerd, Dominik and
                      Repple, Jonathan and Lencer, Rebekka and Dannlowski, Udo and
                      Calhoun, Vince and Rootes-Murdy, Kelly and Demro, Caroline
                      and Ramsay, Ian S. and Sponheim, Scott R. and Schmidt, Andre
                      and Borgwardt, Stefan and Tomyshev, Alexander and Lebedeva,
                      Irina and Höschl, Cyril and Spaniel, Filip and Preda,
                      Adrian and Nguyen, Dana and Uhlmann, Anne and Stein, Dan J.
                      and Howells, Fleur and Temmingh, Henk S. and Diaz Zuluaga,
                      Ana M. and López Jaramillo, Carlos and Iasevoli, Felice and
                      Ji, Ellen and Homan, Stephanie and Omlor, Wolfgang and
                      Homan, Philipp and Kaiser, Stefan and Seifritz, Erich and
                      Misic, Bratislav and Valk, Sofie L. and Thompson, Paul and
                      van Erp, Theo G. M. and Turner, Jessica A. and Bernhardt,
                      Boris and Kirschner, Matthias},
      title        = {{C}onnectome architecture shapes large-scale cortical
                      alterations in schizophrenia: a worldwide {ENIGMA} study},
      journal      = {Molecular psychiatry},
      volume       = {29},
      number       = {6},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2024-05514},
      pages        = {1869 - 1881},
      year         = {2024},
      abstract     = {Schizophrenia is a prototypical network disorder with
                      widespread brain-morphological alterations, yet it remains
                      unclear whether these distributed alterations robustly
                      reflect the underlying network layout. We tested whether
                      large-scale structural alterations in schizophrenia relate
                      to normative structural and functional connectome
                      architecture, and systematically evaluated robustness and
                      generalizability of these network-level alterations.
                      Leveraging anatomical MRI scans from 2439 adults with
                      schizophrenia and 2867 healthy controls from 26 ENIGMA sites
                      and normative data from the Human Connectome Project
                      (n = 207), we evaluated structural alterations of
                      schizophrenia against two network susceptibility models: (i)
                      hub vulnerability, which examines associations between
                      regional network centrality and magnitude of disease-related
                      alterations; (ii) epicenter mapping, which identifies
                      regions whose typical connectivity profile most closely
                      resembles the disease-related morphological alterations. To
                      assess generalizability and specificity, we contextualized
                      the influence of site, disease stages, and individual
                      clinical factors and compared network associations of
                      schizophrenia with that found in affective disorders. Our
                      findings show schizophrenia-related cortical thinning is
                      spatially associated with functional and structural hubs,
                      suggesting that highly interconnected regions are more
                      vulnerable to morphological alterations. Predominantly
                      temporo-paralimbic and frontal regions emerged as epicenters
                      with connectivity profiles linked to schizophrenia’s
                      alteration patterns. Findings were robust across sites,
                      disease stages, and related to individual symptoms.
                      Moreover, transdiagnostic comparisons revealed overlapping
                      epicenters in schizophrenia and bipolar, but not major
                      depressive disorder, suggestive of a pathophysiological
                      continuity within the schizophrenia-bipolar-spectrum. In
                      sum, cortical alterations over the course of schizophrenia
                      robustly follow brain network architecture, emphasizing
                      marked hub susceptibility and temporo-frontal epicenters at
                      both the level of the group and the individual. Subtle
                      variations of epicenters across disease stages suggest
                      interacting pathological processes, while associations with
                      patient-specific symptoms support additional
                      inter-individual variability of hub vulnerability and
                      epicenters in schizophrenia. Our work outlines potential
                      pathways to better understand macroscale structural
                      alterations, and inter- individual variability in
                      schizophrenia.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5251 - Multilevel Brain
                      Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38336840},
      UT           = {WOS:001159797300001},
      doi          = {10.1038/s41380-024-02442-7},
      url          = {https://juser.fz-juelich.de/record/1030921},
}