TY  - CONF
AU  - Yoo, Seulki
AU  - Jang, Yurim
AU  - Hong, Seok-Jun
AU  - Park, Hyunjin
AU  - Valk, Sofie L.
AU  - Bernhardt, Boris C.
AU  - Park, Bo-Yong
TI  - Atypical structural connectome asymmetry and associations with network communication in autism spectrum disorder
PB  - IEEE
M1  - FZJ-2024-05523
SP  - .
PY  - 2023
AB  - Autism spectrum disorder is a common neurodevelopmental condition showing connectome disorganization in sensory and transmodal cortices. However, alterations in the inter-hemispheric asymmetry of structural connectome are remained to be investigated. Here, we studied structural connectome asymmetry in individuals with autism using dimensionality reduction techniques and assessed its topological underpinnings by associating with network communication measures. We found that the sensory and heteromodal association regions showed significant between-group differences in inter-hemispheric asymmetry between individuals with autism and neurotypical controls. In addition, the network communication ability was particularly altered between visual and limbic areas. Our findings provide insights for understanding structural connectome alteration in autism and its topological underpinnings.Clinical Relevance— This study provides insights into the understanding of atypical macroscale structural connectome organization in individuals with autism.
T2  - 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
CY  - 24 Jul 2023 - 27 Jul 2023, Sydney (Australia)
Y2  - 24 Jul 2023 - 27 Jul 2023
M2  - Sydney, Australia
LB  - PUB:(DE-HGF)8 ; PUB:(DE-HGF)7
C6  - 38082728
UR  - <Go to ISI:>//WOS:001133788300086
DO  - DOI:10.1109/EMBC40787.2023.10340029
UR  - https://juser.fz-juelich.de/record/1030931
ER  -