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@ARTICLE{Gell:1030939,
      author       = {Gell, Martin and Langner, Robert and Küppers, Vincent and
                      Cieslik, Edna C. and Satterthwaite, Theodore D. and
                      Eickhoff, Simon B. and Müller, Veronika I.},
      title        = {{C}harting the brain networks of impulsivity:
                      {M}eta-analytic synthesis, functional connectivity modelling
                      and neurotransmitter associations},
      journal      = {Imaging neuroscience},
      volume       = {2},
      issn         = {2837-6056},
      address      = {Cambridge, MA},
      publisher    = {MIT Press},
      reportid     = {FZJ-2024-05530},
      pages        = {1-22},
      year         = {2024},
      note         = {This study was supported by the Deutsche
                      Forschungsgemeinschaft (DFG, GermanResearch Foundation) –
                      269953372/GRK2150; 69953372/GRK2150, EI816/11-1;
                      and431549029/SFB1451, Jülich-Aachen Research Alliance
                      (JARA), the National Institute ofMental Health
                      (R01-MH074457), the Helmholtz Portfolio Theme
                      "Supercomputing andModeling for the Human Brain“, and the
                      European Union’s Horizon 2020 Research andInnovation
                      Programme under Grant Agreement No. 945539 (HBP SGA3)},
      abstract     = {Impulsivity is a multidimensional construct that plays a
                      crucial role in human behaviour and is believed to be a
                      transdiagnostic marker of several psychiatric disorders.
                      However, given its multifaceted nature, investigations of
                      its neural correlates are challenging and systematic
                      comparisons across dimensions are lacking. In this study, we
                      used a comprehensive multi-modal approach to investigate the
                      functional network organisation of two dimensions in which
                      impulsivity manifests: decision-making and response
                      inhibition. ALE meta-analyses of task-based fMRI studies
                      within each dimension identified two distinct and
                      non-overlapping functional systems. One located in the
                      default-mode network, associated with value-based judgments
                      and goal-directed decision-making, and the other distributed
                      across higher-order networks associated with cognitive
                      control. Resting-state functional connectivity revealed the
                      two systems were organised into four specialised communities
                      of default-mode, cingulo-insular, frontoparietal, and
                      temporal regions. Finally, given the widespread use of
                      neurotransmitter-acting medication to treat conditions with
                      impulsive symptoms, we investigated the association between
                      this organisation and neurochemistry and found that
                      integration across communities was associated with
                      PET-derived serotonin receptor density. Our findings
                      reinforce insights from previous behavioural research and
                      provide substantial evidence for the multidimensional nature
                      of impulsivity on the neural level. This highlights the
                      necessity for a comprehensive dimensional ontology on all
                      levels of investigation to address impulsivity in a
                      transdiagnostic manner.},
      cin          = {INM-7},
      ddc          = {050},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / JL SMHB - Joint Lab Supercomputing and Modeling
                      for the Human Brain (JL SMHB-2021-2027)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-Juel1)JL SMHB-2021-2027},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40800313},
      UT           = {WOS:001529784400032},
      doi          = {10.1162/imag_a_00295},
      url          = {https://juser.fz-juelich.de/record/1030939},
}