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001030941 0247_ $$2doi$$a10.7554/eLife.87634.4
001030941 0247_ $$2datacite_doi$$a10.34734/FZJ-2024-05532
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001030941 1001_ $$0P:(DE-Juel1)173843$$aValk, Sofie Louise$$b0$$eCorresponding author
001030941 245__ $$aDifferential increase of hippocampal subfield volume after socio-affective mental training relates to reductions in diurnal cortisol
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001030941 520__ $$aThe hippocampus is a central modulator of the HPA-axis, impacting the regulation of stress on brain structure, function, and behavior. The current study assessed whether three different types of 3 months mental Training Modules geared towards nurturing (a) attention-based mindfulness, (b) socio-affective, or (c) socio-cognitive skills may impact hippocampal organization by reducing stress. We evaluated mental training-induced changes in hippocampal subfield volume and intrinsic functional connectivity, by combining longitudinal structural and resting-state fMRI connectivity analysis in 332 healthy adults. We related these changes to changes in diurnal and chronic cortisol levels. We observed increases in bilateral cornu ammonis volume (CA1-3) following the 3 months compassion-based module targeting socio-affective skills (Affect module), as compared to socio-cognitive skills (Perspective module) or a waitlist cohort with no training intervention. Structural changes were paralleled by relative increases in functional connectivity of CA1-3 when fostering socio-affective as compared to socio-cognitive skills. Furthermore, training-induced changes in CA1-3 structure and function consistently correlated with reductions in cortisol output. Notably, using a multivariate approach, we found that other subfields that did not show group-level changes also contributed to changes in cortisol levels. Overall, we provide a link between a socio-emotional behavioural intervention, changes in hippocampal subfield structure and function, and reductions in cortisol in healthy adults.
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001030941 7001_ $$0P:(DE-HGF)0$$aEngert, Veronika$$b1
001030941 7001_ $$0P:(DE-HGF)0$$aPuhlmann, Lara$$b2
001030941 7001_ $$0P:(DE-HGF)0$$aLinz, Roman$$b3
001030941 7001_ $$0P:(DE-HGF)0$$aCaldairou, Benoit$$b4
001030941 7001_ $$0P:(DE-HGF)0$$aBernasconi, Andrea$$b5
001030941 7001_ $$0P:(DE-HGF)0$$aBernasconi, Neda$$b6
001030941 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C$$b7
001030941 7001_ $$0P:(DE-HGF)0$$aSinger, Tania$$b8
001030941 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.87634.4$$gVol. 12, p. RP87634$$pRP87634$$teLife$$v12$$x2050-084X$$y2024
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001030941 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a       Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Institute for System Neurosciences, Heinrich Heine University, Düsseldorf$$b0
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