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@ARTICLE{Valk:1030941,
      author       = {Valk, Sofie Louise and Engert, Veronika and Puhlmann, Lara
                      and Linz, Roman and Caldairou, Benoit and Bernasconi, Andrea
                      and Bernasconi, Neda and Bernhardt, Boris C and Singer,
                      Tania},
      title        = {{D}ifferential increase of hippocampal subfield volume
                      after socio-affective mental training relates to reductions
                      in diurnal cortisol},
      journal      = {eLife},
      volume       = {12},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2024-05532},
      pages        = {RP87634},
      year         = {2024},
      abstract     = {The hippocampus is a central modulator of the HPA-axis,
                      impacting the regulation of stress on brain structure,
                      function, and behavior. The current study assessed whether
                      three different types of 3 months mental Training Modules
                      geared towards nurturing (a) attention-based mindfulness,
                      (b) socio-affective, or (c) socio-cognitive skills may
                      impact hippocampal organization by reducing stress. We
                      evaluated mental training-induced changes in hippocampal
                      subfield volume and intrinsic functional connectivity, by
                      combining longitudinal structural and resting-state fMRI
                      connectivity analysis in 332 healthy adults. We related
                      these changes to changes in diurnal and chronic cortisol
                      levels. We observed increases in bilateral cornu ammonis
                      volume (CA1-3) following the 3 months compassion-based
                      module targeting socio-affective skills (Affect module), as
                      compared to socio-cognitive skills (Perspective module) or a
                      waitlist cohort with no training intervention. Structural
                      changes were paralleled by relative increases in functional
                      connectivity of CA1-3 when fostering socio-affective as
                      compared to socio-cognitive skills. Furthermore,
                      training-induced changes in CA1-3 structure and function
                      consistently correlated with reductions in cortisol output.
                      Notably, using a multivariate approach, we found that other
                      subfields that did not show group-level changes also
                      contributed to changes in cortisol levels. Overall, we
                      provide a link between a socio-emotional behavioural
                      intervention, changes in hippocampal subfield structure and
                      function, and reductions in cortisol in healthy adults.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.7554/eLife.87634.4},
      url          = {https://juser.fz-juelich.de/record/1030941},
}