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| Home > Publications database > Differential increase of hippocampal subfield volume after socio-affective mental training relates to reductions in diurnal cortisol > print |
| 001 | 1030941 | ||
| 005 | 20250625202305.0 | ||
| 024 | 7 | _ | |a 10.7554/eLife.87634.4 |2 doi |
| 024 | 7 | _ | |a 10.34734/FZJ-2024-05532 |2 datacite_doi |
| 037 | _ | _ | |a FZJ-2024-05532 |
| 082 | _ | _ | |a 600 |
| 100 | 1 | _ | |a Valk, Sofie Louise |0 P:(DE-Juel1)173843 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Differential increase of hippocampal subfield volume after socio-affective mental training relates to reductions in diurnal cortisol |
| 260 | _ | _ | |a Cambridge |c 2024 |b eLife Sciences Publications |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The hippocampus is a central modulator of the HPA-axis, impacting the regulation of stress on brain structure, function, and behavior. The current study assessed whether three different types of 3 months mental Training Modules geared towards nurturing (a) attention-based mindfulness, (b) socio-affective, or (c) socio-cognitive skills may impact hippocampal organization by reducing stress. We evaluated mental training-induced changes in hippocampal subfield volume and intrinsic functional connectivity, by combining longitudinal structural and resting-state fMRI connectivity analysis in 332 healthy adults. We related these changes to changes in diurnal and chronic cortisol levels. We observed increases in bilateral cornu ammonis volume (CA1-3) following the 3 months compassion-based module targeting socio-affective skills (Affect module), as compared to socio-cognitive skills (Perspective module) or a waitlist cohort with no training intervention. Structural changes were paralleled by relative increases in functional connectivity of CA1-3 when fostering socio-affective as compared to socio-cognitive skills. Furthermore, training-induced changes in CA1-3 structure and function consistently correlated with reductions in cortisol output. Notably, using a multivariate approach, we found that other subfields that did not show group-level changes also contributed to changes in cortisol levels. Overall, we provide a link between a socio-emotional behavioural intervention, changes in hippocampal subfield structure and function, and reductions in cortisol in healthy adults. |
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| 700 | 1 | _ | |a Linz, Roman |0 P:(DE-HGF)0 |b 3 |
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| 700 | 1 | _ | |a Singer, Tania |0 P:(DE-HGF)0 |b 8 |
| 773 | _ | _ | |a 10.7554/eLife.87634.4 |g Vol. 12, p. RP87634 |0 PERI:(DE-600)2687154-3 |p RP87634 |t eLife |v 12 |y 2024 |x 2050-084X |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1030941/files/elife-87634-v1.pdf |y OpenAccess |
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| 910 | 1 | _ | |a Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Institute for System Neurosciences, Heinrich Heine University, Düsseldorf |0 I:(DE-HGF)0 |b 0 |6 P:(DE-Juel1)173843 |
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