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@ARTICLE{Kchenhoff:1030942,
      author       = {Küchenhoff, Svenja and Bayrak, Şeyma and Zsido, Rachel G.
                      and Saberi, Amin and Bernhardt, Boris C. and Weis, Susanne
                      and Schaare, H. Lina and Sacher, Julia and Eickhoff, Simon
                      and Valk, Sofie L.},
      title        = {{R}elating sex-bias in human cortical and hippocampal
                      microstructure to sex hormones},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2024-05533},
      pages        = {7279},
      year         = {2024},
      abstract     = {Determining sex-bias in brain structure is of great
                      societal interest to improve diagnostics and treatment of
                      brain-related disorders. So far, studies on sex-bias in
                      brain structure predominantly focus on macro-scale measures,
                      and often ignore factors determining this bias. Here we
                      study sex-bias in cortical and hippocampal microstructure in
                      relation to sex hormones. Investigating quantitative
                      intracortical profiling in-vivo using the T1w/T2w ratio in
                      1093 healthy females and males of the cross-sectional Human
                      Connectome Project young adult sample, we find that regional
                      cortical and hippocampal microstructure differs between
                      males and females and that the effect size of this sex-bias
                      varies depending on self-reported hormonal status in
                      females. Microstructural sex-bias and expression of sex
                      hormone genes, based on an independent post-mortem sample,
                      are spatially coupled. Lastly, sex-bias is most pronounced
                      in paralimbic areas, with low laminar complexity, which are
                      predicted to be most plastic based on their
                      cytoarchitectural properties. Albeit correlative, our study
                      underscores the importance of incorporating sex hormone
                      variables into the investigation of brain structure and
                      plasticity.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39179555},
      UT           = {WOS:001297184000034},
      doi          = {10.1038/s41467-024-51459-7},
      url          = {https://juser.fz-juelich.de/record/1030942},
}