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@ARTICLE{Jiang:1031205,
      author       = {Jiang, Han-Jia and Qi, Guanxiao and Duarte, Renato and
                      Feldmeyer, Dirk and van Albada, Sacha},
      title        = {{A} {L}ayered {M}icrocircuit {M}odel of {S}omatosensory
                      {C}ortex with {T}hree {I}nterneuron {T}ypes and
                      {C}ell-{T}ype-{S}pecific {S}hort-{T}erm {P}lasticity},
      journal      = {Cerebral cortex},
      volume       = {34},
      number       = {9},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2024-05605},
      pages        = {bhae378},
      year         = {2024},
      abstract     = {Three major types of GABAergic interneurons, parvalbumin-,
                      somatostatin-, and vasoactive intestinal peptide-expressing
                      (PV, SOM, VIP) cells, play critical but distinct roles in
                      the cortical microcircuitry. Their specific
                      electrophysiology and connectivity shape their inhibitory
                      functions. To study the network dynamics and signal
                      processing specific to these cell types in the cerebral
                      cortex, we developed a multi-layer model incorporating
                      biologically realistic interneuron parameters from rodent
                      somatosensory cortex. The model is fitted to in vivo data on
                      cell-type-specific population firing rates. With a protocol
                      of cell-type-specific stimulation, network responses when
                      activating different neuron types are examined. The model
                      reproduces the experimentally observed inhibitory effects of
                      PV and SOM cells and disinhibitory effect of VIP cells on
                      excitatory cells. We further create a version of the model
                      incorporating cell-type-specific short-term synaptic
                      plasticity (STP). While the ongoing activity with and
                      without STP is similar, STP modulates the responses of Exc,
                      SOM, and VIP cells to cell-type-specific stimulation,
                      presumably by changing the dominant inhibitory pathways.
                      With slight adjustments, the model also reproduces sensory
                      responses of specific interneuron types recorded in vivo.
                      Our model provides predictions on network dynamics involving
                      cell-type-specific short-term plasticity and can serve to
                      explore the computational roles of inhibitory interneurons
                      in sensory functions.},
      cin          = {IAS-6 / INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IAS-6-20130828 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523) / HBP SGA3 -
                      Human Brain Project Specific Grant Agreement 3 (945539) /
                      EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to
                      Advance Neuroscience and Brain Health (101147319) / DFG
                      project G:(GEPRIS)491111487 - Open-Access-Publikationskosten
                      / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ)
                      (491111487)},
      pid          = {G:(DE-HGF)POF4-5231 / G:(EU-Grant)945539 /
                      G:(EU-Grant)101147319 / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39344196},
      UT           = {WOS:001321447500001},
      doi          = {10.1093/cercor/bhae378},
      url          = {https://juser.fz-juelich.de/record/1031205},
}