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@ARTICLE{Pronold:1031473,
      author       = {Pronold, Jari and van Meegen, Alexander and Shimoura, Renan
                      O and Vollenbröker, Hannah and Senden, Mario and Hilgetag,
                      Claus C and Bakker, Rembrandt and van Albada, Sacha J},
      title        = {{M}ulti-{S}cale {S}piking {N}etwork {M}odel of {H}uman
                      {C}erebral {C}ortex},
      journal      = {Cerebral cortex},
      volume       = {34},
      number       = {10},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2024-05686},
      pages        = {bhae409},
      year         = {2024},
      abstract     = {Although the structure of cortical networks provides the
                      necessary substrate for their neuronal activity, the
                      structure alone does not suffice to understand the activity.
                      Leveraging the increasing availability of human data, we
                      developed a multi-scale, spiking network model of human
                      cortex to investigate the relationship between structure and
                      dynamics. In this model, each area in one hemisphere of the
                      Desikan–Killiany parcellation is represented by a 1 $mm^2$
                      column with a layered structure. The model aggregates data
                      across multiple modalities, including electron microscopy,
                      electrophysiology, morphological reconstructions, and
                      diffusion tensor imaging, into a coherent framework. It
                      predicts activity on all scales from the single-neuron
                      spiking activity to the area-level functional connectivity.
                      We compared the model activity with human
                      electrophysiological data and human resting-state functional
                      magnetic resonance imaging (fMRI) data. This comparison
                      reveals that the model can reproduce aspects of both spiking
                      statistics and fMRI correlations if the inter-areal
                      connections are sufficiently strong. Furthermore, we study
                      the propagation of a single-spike perturbation and
                      macroscopic fluctuations through the network. The
                      open-source model serves as an integrative platform for
                      further refinements and future in silico studies of human
                      cortical structure, dynamics, and function.},
      cin          = {IAS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IAS-6-20130828},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523) / DFG project
                      G:(GEPRIS)347572269 - Heterogenität von Zytoarchitektur,
                      Chemoarchitektur und Konnektivität in einem großskaligen
                      Computermodell der menschlichen Großhirnrinde (347572269) /
                      HBP SGA3 - Human Brain Project Specific Grant Agreement 3
                      (945539) / EBRAINS 2.0 - EBRAINS 2.0: A Research
                      Infrastructure to Advance Neuroscience and Brain Health
                      (101147319) / JL SMHB - Joint Lab Supercomputing and
                      Modeling for the Human Brain (JL SMHB-2021-2027) / Helmholtz
                      Platform for Research Software Engineering - Preparatory
                      Study $(HiRSE_PS-20220812)$ / Brain-Scale Simulations
                      $(jinb33_20220812)$ / DFG project G:(GEPRIS)491111487 -
                      Open-Access-Publikationskosten / 2022 - 2024 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5231 / G:(GEPRIS)347572269 /
                      G:(EU-Grant)945539 / G:(EU-Grant)101147319 / G:(DE-Juel1)JL
                      SMHB-2021-2027 / $G:(DE-Juel-1)HiRSE_PS-20220812$ /
                      $G:(DE-Juel1)jinb33_20220812$ / G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39428578},
      UT           = {WOS:001336208500001},
      doi          = {10.1093/cercor/bhae409},
      url          = {https://juser.fz-juelich.de/record/1031473},
}