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@ARTICLE{Grande:1031506,
      author       = {Grande, Philipp and Schoofs, Leonie and Weidener, Dennis
                      and Leitner, Walter and Klose, Holger},
      title        = {{L}ignocellulose {T}reatment {U}sing a {F}low‐{T}hrough
                      {V}ariant of {O}rgano{C}at {P}rocess},
      journal      = {ChemSusChem},
      volume       = {18},
      number       = {3},
      issn         = {1864-5631},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2024-05708},
      pages        = {e202401063},
      year         = {2025},
      abstract     = {This study adapts the biphasic OrganoCat system into a
                      flow-through (FT) reactor, using a heated tubular setup
                      where a mixture of oxalic acid and 2-methyltetrahydrofuran
                      (2-MTHF) is pumped through beech wood biomass. This method
                      minimizes solvent-biomass contact time, facilitating rapid
                      product removal and reducing the risk of secondary
                      reactions. A comparative analysis with traditional batch
                      processes reveals that the FT system, especially under
                      severe conditions, significantly enhances extraction
                      efficiency, yielding higher amounts of lignin and sugars
                      with reduced solid residue. Notably, the FT system doubles
                      the sugar yield under harsh conditions compared to the batch
                      process, with a slight increase in lignin yield, indicating
                      more efficient depolymerization of polysaccharides without
                      substantial sugar degradation. A statistical design of
                      experiments (DOE) using a Box-Behnken design elucidates the
                      influence of process variables (time, solvent flow rate,
                      temperature) on the yield. Key findings highlight reactor
                      temperature as the dominant factor affecting yields, with
                      process time showing a significant but less pronounced
                      impact. This study demonstrates the potential of the FT
                      OrganoCat system for efficient lignocellulosic biomass
                      fractionation and represents an advancement towards
                      continuous lignocellulose processing, contributing to our
                      knowledge of process optimization for improved biorefinery
                      applications.},
      cin          = {IBG-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39319399},
      UT           = {WOS:001357119100001},
      doi          = {10.1002/cssc.202401063},
      url          = {https://juser.fz-juelich.de/record/1031506},
}