001031973 001__ 1031973
001031973 005__ 20241108205839.0
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001031973 041__ $$aEnglish
001031973 1001_ $$0P:(DE-Juel1)144576$$aIto, Junji$$b0$$eCorresponding author$$ufzj
001031973 1112_ $$aSeeing and Acting Workshop: Functional and Neural Perspectives$$cCoimbra$$d2024-09-26 - 2024-09-28$$gSAW2024$$wPortugal
001031973 245__ $$aSensory and behavioural tuning along the dorsal pathway
001031973 260__ $$c2024
001031973 3367_ $$033$$2EndNote$$aConference Paper
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001031973 520__ $$aDirectional tuning of motor cortex neurons is typically characterized by a sinusoidal tuning curve with a preferred direction (PD) represented by its peak. While PDs across neurons were assumed to be uniformly distributed over all directions, recent experiments reported a bimodal distribution of hand movement PDs when the movements are constrained to a horizontal work area. Several modelling studies attribute this to the limb biomechanics, which indicates more kinetic (muscle force based) rather than kinematic (movement parameter based) representation in the motor cortex. We conducted neuronal recordings in behaving macaques to elucidate to what extent this kinetic tuning extends down along the dorsal pathway. The monkeys were trained for a visually guided reaching task in the horizontal plane. Spiking activity was recorded in visual (V1/V2), parietal (DP, 7A) and motor (M1/PMd) areas. To estimate the tuning curve of each neuron to sensory and behavioural modalities, we regressed the spiking activity of each neuron on all available behavioural and sensory covariates (visual input, eye/hand position, saccade, hand movement direction and speed) at once by using generalized linear models. The model fitting results reveal a gradual shift in visual and motor tuning along the dorsal pathway: increasing of motor and decreasing of visual tuning towards the motor cortex. We confirm the bimodal hand movement PD distribution in M1/PMd, and also find, after eliminating the confounding effect of the visual tuning, similar bimodal PD distributions in V1/V2, DP and 7A, suggesting an influence of limb biomechanics even in the lower hierarchy levels of the dorsal visual stream.
001031973 536__ $$0G:(DE-HGF)POF4-5231$$a5231 - Neuroscientific Foundations (POF4-523)$$cPOF4-523$$fPOF IV$$x0
001031973 536__ $$0G:(EU-Grant)785907$$aHBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907)$$c785907$$fH2020-SGA-FETFLAG-HBP-2017$$x1
001031973 536__ $$0G:(EU-Grant)945539$$aHBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)$$c945539$$fH2020-SGA-FETFLAG-HBP-2019$$x2
001031973 536__ $$0G:(DE-HGF)ZT-I-0003$$aHAF - Helmholtz Analytics Framework (ZT-I-0003)$$cZT-I-0003$$x3
001031973 536__ $$0G:(DE-Juel1)JL SMHB-2021-2027$$aJL SMHB - Joint Lab Supercomputing and Modeling for the Human Brain (JL SMHB-2021-2027)$$cJL SMHB-2021-2027$$x4
001031973 536__ $$0G:(DE-Juel-1)iBehave-20220812$$aAlgorithms of Adaptive Behavior and their Neuronal Implementation in Health and Disease (iBehave-20220812)$$ciBehave-20220812$$x5
001031973 536__ $$0G:(GEPRIS)368482240$$aGRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240)$$c368482240$$x6
001031973 7001_ $$0P:(DE-Juel1)176777$$aEssink, Simon$$b1$$ufzj
001031973 7001_ $$0P:(DE-Juel1)172858$$aRiehle, Alexa$$b2
001031973 7001_ $$0P:(DE-HGF)0$$aBrochier, Thomas$$b3
001031973 7001_ $$0P:(DE-Juel1)144168$$aGrün, Sonja$$b4$$ufzj
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001031973 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144576$$aForschungszentrum Jülich$$b0$$kFZJ
001031973 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)176777$$aForschungszentrum Jülich$$b1$$kFZJ
001031973 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144168$$aForschungszentrum Jülich$$b4$$kFZJ
001031973 9131_ $$0G:(DE-HGF)POF4-523$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5231$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vNeuromorphic Computing and Network Dynamics$$x0
001031973 9141_ $$y2024
001031973 9201_ $$0I:(DE-Juel1)IAS-6-20130828$$kIAS-6$$lComputational and Systems Neuroscience$$x0
001031973 9201_ $$0I:(DE-Juel1)INM-10-20170113$$kINM-10$$lJara-Institut Brain structure-function relationships$$x1
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