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@ARTICLE{Saberi:1032008,
      author       = {Saberi, Amin and Ebneabbasi, Amir and Rahimi, Sama and
                      Sarebannejad, Sara and Sen, Zumrut Duygu and Graf, Heiko and
                      Walter, Martin and Sorg, Christian and Camilleri, Julia and
                      Laird, Angela R. and Fox, Peter T. and Valk, Sofie L. and
                      Eickhoff, Simon B. and Tahmasian, Masoud},
      title        = {{C}onvergent functional effects of antidepressants in major
                      depressive disorder: a neuroimaging meta-analysis},
      journal      = {Molecular psychiatry},
      volume       = {30},
      issn         = {1359-4184},
      address      = {London},
      publisher    = {Macmillan},
      reportid     = {FZJ-2024-05924},
      pages        = {736–751},
      year         = {2025},
      abstract     = {BackgroundNeuroimaging studies have provided valuable
                      insights into the macroscale impacts of antidepressants on
                      brain functions in patients with major depressive disorder.
                      However, the findings of individual studies are
                      inconsistent. Here, we aimed to provide a quantitative
                      synthesis of the literature to identify convergence of the
                      reported findings at both regional and network levels and to
                      examine their associations with neurotransmitter
                      systems.MethodsThrough a comprehensive search in PubMed and
                      Scopus databases, we reviewed 5258 abstracts and identified
                      36 eligible functional neuroimaging studies on
                      antidepressant effects in major depressive disorder.
                      Activation likelihood estimation was used to investigate
                      regional convergence of the reported foci of antidepressant
                      effects, followed by functional decoding and connectivity
                      mapping of the convergent clusters. Additionally, utilizing
                      group-averaged data from the Human Connectome Project, we
                      assessed convergent resting-state functional connectivity
                      patterns of the reported foci. Next, we compared the
                      convergent circuit with the circuits targeted by
                      transcranial magnetic stimulation therapy. Last, we studied
                      the association of regional and network-level convergence
                      maps with selected neurotransmitter receptors/transporters
                      maps.ResultsNo regional convergence was found across foci of
                      treatment-associated alterations in functional imaging.
                      Subgroup analysis in the Treated > Untreated contrast
                      revealed a convergent cluster in the left dorsolateral
                      prefrontal cortex, which was associated with working memory
                      and attention behavioral domains. Moreover, we found
                      network-level convergence of the treatment-associated
                      alterations in a circuit more prominent in the
                      frontoparietal areas. This circuit was co-aligned with
                      circuits targeted by “anti-subgenual” and “Beam F3”
                      transcranial magnetic stimulation therapy. We observed no
                      significant correlations between our meta-analytic findings
                      with the maps of neurotransmitter
                      receptors/transporters.ConclusionOur findings highlight the
                      importance of the frontoparietal network and the left
                      dorsolateral prefrontal cortex in the therapeutic effects of
                      antidepressants, which may relate to their role in improving
                      executive functions and emotional processing.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39406999},
      UT           = {WOS:001332746300003},
      doi          = {10.1038/s41380-024-02780-6},
      url          = {https://juser.fz-juelich.de/record/1032008},
}