TY  - JOUR
AU  - Goerttler, Tsepo
AU  - Dorner, Martin B.
AU  - van der Linden, Christina
AU  - Kienitz, Ricardo
AU  - Petrik, Stephan
AU  - Blechinger, Stephan
AU  - Spickschen, Jonah
AU  - Betz, Iris R.
AU  - Hinrichs, Carl
AU  - Steindl, David
AU  - Weber, Frederike
AU  - Musacchio, Thomas
AU  - Wunderlich, Gilbert
AU  - Rueger, Maria Adele
AU  - Barbe, Michael T.
AU  - Dafsari, Haidar
AU  - Demir, Seda
AU  - Lapa, Sriramya
AU  - Zeiner, Pia S.
AU  - Strzelczyk, Adam
AU  - Tinnemann, Peter
AU  - Kleine, Christian
AU  - Totzeck, Andreas
AU  - Klebe, Stephan
AU  - Mikolajewska, Agata
AU  - Dorner, Brigitte G.
AU  - Fertl, Elisabeth
AU  - Grefkes-Hermann, Christian
AU  - Fink, Gereon
AU  - Kleinschnitz, Christoph
AU  - Hagenacker, Tim
TI  - Iatrogenic botulism after intragastric botulinum neurotoxin injections – a major outbreak
JO  - Neurological research and practice
VL  - 6
IS  - 1
SN  - 2524-3489
CY  - [London]
PB  - BioMed Central
M1  - FZJ-2024-06248
SP  - 52
PY  - 2024
N1  - Supported by the DFG in the framework of the DFG Clinician Scientist Programme UMEA, FU356/12-2
AB  - AbstractBackgroundIntragastric botulinum neurotoxin injections (IBNI) are offered off-label in the private medical sector in a few European countries as a safe and effective weight-loss measure. In February and March 2023, an outbreak of iatrogenic botulism occurred in several European countries following IBNI treatment in Turkey. This case series describes the clinical features of severe iatrogenic botulism after IBNI.MethodsWe retrospectively summarize the clinical course and emergency department and intensive care unit interventions in ten cases of severe iatrogenic botulism that occurred after receiving IBNI in this sudden outbreak in Austria and Germany.ResultsSeven out of ten cases initially showed characteristic symptoms of botulism with diplopia, dysphagia, dysarthria, dysarthrophonia, and descending paralysis. All patients were hospitalized, six in an intensive care unit and partially requiring mechanical ventilation. All patients recovered and were discharged without relevant permanent deficits.ConclusionOur study highlights ten clinical cases in this iatrogenic botulism outbreak, representing the largest reported outbreak worldwide. Clinicians should be aware of the risks associated with medical procedures involving botulinum neurotoxins and ensure measures to minimize the risk of iatrogenic botulism.
LB  - PUB:(DE-HGF)16
C6  - 39472968
UR  - <Go to ISI:>//WOS:001344817300001
DO  - DOI:10.1186/s42466-024-00350-3
UR  - https://juser.fz-juelich.de/record/1032442
ER  -