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@ARTICLE{Pils:1032444,
      author       = {Pils, Marlene and Dybala, Alexandra and Schaffrath, Anja
                      and Rehn, Fabian and Kutzsche, Janine and Blömeke, Lara and
                      Tusche, Markus and Özdüzenciler, Pelin and Bujnicki, Tuyen
                      and Kraemer-Schulien, Victoria and Gramespacher, Hannes and
                      Schmieschek, Maximilian H. T. and Barbe, Michael T. and
                      Onur, Oezguer A. and Fink, Gereon R. and Tamgüney,
                      Gültekin and Bannach, Oliver and Willbold, Dieter},
      title        = {{E}levated {A}β aggregates in feces from {A}lzheimer’s
                      disease patients: a proof-of-concept study},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {16},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2024-06250},
      pages        = {223},
      year         = {2024},
      note         = {sFIDA was supported by the programs “Biomarkers Across
                      Neurodegenerative Diseases I + II” of The Alzheimer’s
                      Association, Alzheimer’s Research UK, and the Weston Brain
                      Institute [11084, BAND-19-614337]. We are also grateful for
                      support from The Michael J. Fox Foundation for Parkinson’s
                      Research [14977, 009889], the ALS Association, and the
                      Packard Center [19-SI-476]. We received further funding from
                      the Deutsche Forschungsgemeinschaft [INST 208/616-1 FUGG,
                      INST 208/794-1 FUGG], Helmholtz Association [HVF0079],
                      Förderstiftung Dierichs, and Deutsche Alzheimer
                      Gesellschaft e.V. Selbsthilfe Demenz (DalzG). G.R.F. and
                      O.A.O. were supported by the Marga and Walter
                      Boll-Foundation. H.G. was supported by the Cologne Clinician
                      Scientist Program (CCSP) / Faculty of Medicine / University
                      of Cologne and received funding from Deutsche
                      Forschungsgemeinschaft [DFG, FI 773/15 − 1].Open Access
                      funding enabled and organized by Projekt DEAL.},
      abstract     = {BackgroundMisfolding and aggregation of amyloid β (Aβ),
                      along with neurofibrillary tangles consisting of aggregated
                      Tau species, are pathological hallmarks of Alzheimer’s
                      disease (AD) onset and progression. In this study, we
                      hypothesized the clearance of Aβ aggregates from the brain
                      and body into the gut.MethodsTo investigate this, we used
                      surface-based fluorescence intensity distribution analysis
                      (sFIDA) to determine the Aβ aggregate concentrations in
                      feces from 26 AD patients and 31 healthy controls
                      (HC).ResultsAβ aggregates were detectable in human feces
                      and their concentrations were elevated in AD patients
                      compared to HC (specificity $90.3\%,$ sensitivity
                      $53.8\%).ConclusionThus,$ fecal Aβ aggregates constitute a
                      non-invasive biomarker candidate for diagnosing AD. Whether
                      digestion-resistant Aβ aggregates in feces are secreted via
                      the liver and bile or directly from the enteric neuronal
                      system remains to be elucidated.},
      cin          = {INM-3 / IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5244 - Information Processing in Neuronal
                      Networks (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39402637},
      UT           = {WOS:001331211400001},
      doi          = {10.1186/s13195-024-01597-3},
      url          = {https://juser.fz-juelich.de/record/1032444},
}