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001032445 1001_ $$0P:(DE-HGF)0$$aSauerbier, Anna$$b0$$eCorresponding author
001032445 245__ $$aSubthalamic Stimulation Improves Short-Term Satisfaction with Life and Treatment in Parkinson’s Disease
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001032445 520__ $$aThe effect of subthalamic stimulation (STN-DBS) on patients’ personal satisfaction with life and their Parkinson’s disease (PD) treatment is understudied, as is its correlation with quality of life (QoL). Therefore, we tested the hypothesis that STN-DBS for PD enhances satisfaction with life and treatment. In a prospective, multicenter study with a 6-month follow-up involving 121 patients, we measured the main outcomes using the Satisfaction with Life and Treatment Scale (SLTS-7). Secondary outcomes included the eight-item PD Questionnaire (PDQ-8), European QoL Questionnaire (EQ-5D-3L), EQ-Visual Analogue Scale (VAS), Non-Motor Symptom Scale (NMSS), Hospital Anxiety and Depression Scale (HADS), and Unified PD Rating Scale (UPDRS). Longitudinal outcome changes, effect sizes (Cohen’s d), and correlations between outcome changes were analyzed. SLTS-7 scores improved at the 6-month follow-up, particularly in the domains of ‘satisfaction with physical health’ and ‘satisfaction with treatment’. Change scores correlated strongly (EQ-VAS), moderately (PDQ-8 SI and HADS), and weakly (UPDRS-activities of daily living and EQ-5D-3L) with other scales. Satisfaction with physical health, psychosocial well-being, or treatment was not related to UPDRS-motor examination. This study provides evidence that STN-DBS enhances patients’ personal satisfaction with life and treatment. This satisfaction is associated with improvements in the QoL, daily activities, and neuropsychiatric aspects of PD rather than its motor aspects.Keywords: treatment satisfaction, life satisfaction, quality of life, deep brain stimulation, non-motor symptoms
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001032445 7001_ $$00009-0002-4614-4029$$aBachon, Pia$$b1
001032445 7001_ $$0P:(DE-HGF)0$$aAmbrosio, Leire$$b2
001032445 7001_ $$00000-0002-5279-2156$$aLoehrer, Philipp A.$$b3
001032445 7001_ $$0P:(DE-HGF)0$$aRizos, Alexandra$$b4
001032445 7001_ $$0P:(DE-HGF)0$$aJost, Stefanie T.$$b5
001032445 7001_ $$0P:(DE-HGF)0$$aGronostay, Alexandra$$b6
001032445 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7$$ufzj
001032445 7001_ $$0P:(DE-HGF)0$$aAshkan, Keyoumars$$b8
001032445 7001_ $$00000-0002-8216-9410$$aNimsky, Christopher$$b9
001032445 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b10
001032445 7001_ $$00000-0003-2815-0505$$aChaudhuri, K. Ray$$b11
001032445 7001_ $$0P:(DE-HGF)0$$aTimmermann, Lars$$b12
001032445 7001_ $$00000-0003-0837-5280$$aMartinez-Martin, Pablo$$b13
001032445 7001_ $$00000-0001-8849-4233$$aDafsari, Haidar S.$$b14
001032445 773__ $$0PERI:(DE-600)2662248-8$$a10.3390/jpm14101023$$gVol. 14, no. 10, p. 1023 -$$n10$$p1023 -$$tJournal of Personalized Medicine$$v14$$x2075-4426$$y2024
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