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@ARTICLE{Sauerbier:1032445,
      author       = {Sauerbier, Anna and Bachon, Pia and Ambrosio, Leire and
                      Loehrer, Philipp A. and Rizos, Alexandra and Jost, Stefanie
                      T. and Gronostay, Alexandra and Fink, Gereon R. and Ashkan,
                      Keyoumars and Nimsky, Christopher and Visser-Vandewalle,
                      Veerle and Chaudhuri, K. Ray and Timmermann, Lars and
                      Martinez-Martin, Pablo and Dafsari, Haidar S.},
      title        = {{S}ubthalamic {S}timulation {I}mproves {S}hort-{T}erm
                      {S}atisfaction with {L}ife and {T}reatment in
                      {P}arkinson’s {D}isease},
      journal      = {Journal of Personalized Medicine},
      volume       = {14},
      number       = {10},
      issn         = {2075-4426},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2024-06251},
      pages        = {1023 -},
      year         = {2024},
      abstract     = {The effect of subthalamic stimulation (STN-DBS) on
                      patients’ personal satisfaction with life and their
                      Parkinson’s disease (PD) treatment is understudied, as is
                      its correlation with quality of life (QoL). Therefore, we
                      tested the hypothesis that STN-DBS for PD enhances
                      satisfaction with life and treatment. In a prospective,
                      multicenter study with a 6-month follow-up involving 121
                      patients, we measured the main outcomes using the
                      Satisfaction with Life and Treatment Scale (SLTS-7).
                      Secondary outcomes included the eight-item PD Questionnaire
                      (PDQ-8), European QoL Questionnaire (EQ-5D-3L), EQ-Visual
                      Analogue Scale (VAS), Non-Motor Symptom Scale (NMSS),
                      Hospital Anxiety and Depression Scale (HADS), and Unified PD
                      Rating Scale (UPDRS). Longitudinal outcome changes, effect
                      sizes (Cohen’s d), and correlations between outcome
                      changes were analyzed. SLTS-7 scores improved at the 6-month
                      follow-up, particularly in the domains of ‘satisfaction
                      with physical health’ and ‘satisfaction with
                      treatment’. Change scores correlated strongly (EQ-VAS),
                      moderately (PDQ-8 SI and HADS), and weakly (UPDRS-activities
                      of daily living and EQ-5D-3L) with other scales.
                      Satisfaction with physical health, psychosocial well-being,
                      or treatment was not related to UPDRS-motor examination.
                      This study provides evidence that STN-DBS enhances
                      patients’ personal satisfaction with life and treatment.
                      This satisfaction is associated with improvements in the
                      QoL, daily activities, and neuropsychiatric aspects of PD
                      rather than its motor aspects.Keywords: treatment
                      satisfaction, life satisfaction, quality of life, deep brain
                      stimulation, non-motor symptoms},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3390/jpm14101023},
      url          = {https://juser.fz-juelich.de/record/1032445},
}