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@ARTICLE{Mustin:1032449,
      author       = {Mustin, Maike and Hensel, Lukas and Fink, Gereon R. and
                      Grefkes, Christian and Tscherpel, Caroline},
      title        = {{I}ndividual contralesional recruitment in the context of
                      structural reserve in early motor reorganization after
                      stroke},
      journal      = {NeuroImage},
      volume       = {300},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2024-06255},
      pages        = {120828 -},
      year         = {2024},
      abstract     = {he concept of structural reserve in stroke reorganization
                      assumes that the relevance of the contralesional hemisphere
                      strongly depends on the brain tissue spared by the lesion in
                      the affected hemisphere. Recent studies, however, have
                      indicated that the contralesional hemisphere's impact
                      exhibits region-specific variability with concurrently
                      existing maladaptive and supportive influences. This
                      challenges traditional views, necessitating a nuanced
                      investigation of contralesional motor areas and their
                      interaction with ipsilesional networks.Our study focused on
                      the functional role of contralesional key motor areas and
                      lesion-induced connectome disruption early after
                      stroke.Online TMS data of twenty-five stroke patients was
                      analyzed to disentangle interindividual differences in the
                      functional roles of contralesional primary motor cortex
                      (M1), dorsal premotor cortex (dPMC), and anterior
                      interparietal sulcus (aIPS) for motor function.
                      Connectome-based lesion symptom mapping and corticospinal
                      tract lesion quantification were used to investigate how TMS
                      effects depend on ipsilesional structural network
                      properties.At group and individual levels, TMS interference
                      with contralesional M1 and aIPS but not dPMC led to improved
                      performance early after stroke. At the connectome level, a
                      more disturbing role of contralesional M1 was related to a
                      more severe disruption of the structural integrity of
                      ipsilesional M1 in the affected motor network. In contrast,
                      a detrimental influence of contralesional aIPS was linked to
                      less disruption of the ipsilesional M1 connectivity.Our
                      findings indicate that contralesional areas distinctively
                      interfere with motor performance early after stroke
                      depending on ipsilesional structural integrity, extending
                      the concept of structural reserve to regional specificity in
                      recovery of function.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39293355},
      UT           = {WOS:001318094400001},
      doi          = {10.1016/j.neuroimage.2024.120828},
      url          = {https://juser.fz-juelich.de/record/1032449},
}