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| 001 | 1032449 | ||
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| 100 | 1 | _ | |a Mustin, Maike |0 P:(DE-Juel1)201297 |b 0 |
| 245 | _ | _ | |a Individual contralesional recruitment in the context of structural reserve in early motor reorganization after stroke |
| 260 | _ | _ | |a Orlando, Fla. |c 2024 |b Academic Press |
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| 520 | _ | _ | |a he concept of structural reserve in stroke reorganization assumes that the relevance of the contralesional hemisphere strongly depends on the brain tissue spared by the lesion in the affected hemisphere. Recent studies, however, have indicated that the contralesional hemisphere's impact exhibits region-specific variability with concurrently existing maladaptive and supportive influences. This challenges traditional views, necessitating a nuanced investigation of contralesional motor areas and their interaction with ipsilesional networks.Our study focused on the functional role of contralesional key motor areas and lesion-induced connectome disruption early after stroke.Online TMS data of twenty-five stroke patients was analyzed to disentangle interindividual differences in the functional roles of contralesional primary motor cortex (M1), dorsal premotor cortex (dPMC), and anterior interparietal sulcus (aIPS) for motor function. Connectome-based lesion symptom mapping and corticospinal tract lesion quantification were used to investigate how TMS effects depend on ipsilesional structural network properties.At group and individual levels, TMS interference with contralesional M1 and aIPS but not dPMC led to improved performance early after stroke. At the connectome level, a more disturbing role of contralesional M1 was related to a more severe disruption of the structural integrity of ipsilesional M1 in the affected motor network. In contrast, a detrimental influence of contralesional aIPS was linked to less disruption of the ipsilesional M1 connectivity.Our findings indicate that contralesional areas distinctively interfere with motor performance early after stroke depending on ipsilesional structural integrity, extending the concept of structural reserve to regional specificity in recovery of function. |
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| 700 | 1 | _ | |a Tscherpel, Caroline |0 P:(DE-Juel1)168559 |b 4 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.neuroimage.2024.120828 |g Vol. 300, p. 120828 - |0 PERI:(DE-600)1471418-8 |p 120828 - |t NeuroImage |v 300 |y 2024 |x 1053-8119 |
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