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| Home > Publications database > Multicontrast binding state analysis using frequency mixing magnetic detection |
| Conference Presentation (Other) | FZJ-2024-06320 |
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2024
Abstract: Unique nonlinear magnetic properties of magnetic nanoparticles (MNPs) enable applications beyond a contrast agent, i.e., remote spatiotemporal temperature/viscosity measurement or multi-contrast bioassay. Frequency Mixing Magnetic Detection is a technique that probes the nonlinear properties of the magnetization curve with a dual-tone excitation field. Earlier, we demonstrated multi-contrast reconstruction as a linear combination of original constituents. Recently, we proposed a principle and a measurement technique that allows independent read-out of several contrast agents by determining magnetic moment distribution without any assumptions about the original constituents. In this work, we reconstruct constituent concentration of binary and ternary mixtures of commercially available magnetic particles (SynomagD 50 nm, SynomagD 70 nm, and Perimag 130 nm) and extract additional dynamic information of their binding state by selective agglomeration with a linker molecule. We systematically correlate the FMMD response with static and dynamic magnetic property characterization methods.
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