001032533 001__ 1032533 001032533 005__ 20241120212351.0 001032533 037__ $$aFZJ-2024-06321 001032533 041__ $$aEnglish 001032533 1001_ $$0P:(DE-Juel1)190282$$aBikulov, Timur$$b0$$eCorresponding author$$ufzj 001032533 1112_ $$aInternational Workshop on Magnetic Particle Imaging$$cFlüeli-Ranft$$d2024-03-13 - 2024-03-15$$gIWMPI$$wSwitzerland 001032533 245__ $$aMulticontrasting MPS by dual-tone nonlinearity probing 001032533 260__ $$c2024 001032533 3367_ $$033$$2EndNote$$aConference Paper 001032533 3367_ $$2DataCite$$aOther 001032533 3367_ $$2BibTeX$$aINPROCEEDINGS 001032533 3367_ $$2DRIVER$$aconferenceObject 001032533 3367_ $$2ORCID$$aLECTURE_SPEECH 001032533 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1732097242_20163$$xOther 001032533 520__ $$aNovel MPI-based modalities such as multi-contrast imaging or remote viscosity recording require independent measurement of at least two or more magnetic particle types simultaneously. Particle response models based on the Fokker-Plank equation allow independent reconstruction of core and hydrodynamic diameters. However, due to complexity and stochastic character, they remain a black box for explaining the origin of measured nonlinear distortions. A model is required to suggest which frequency lines to measure, which fields to apply for reconstruction of particle core size distribution, and to explicitly show limitations of setup and measurement scheme (e.g., the range of core diameters available for reconstruction). Assuming that the amplitude of the sample magnetic moment and its distortions are determined by the number of excited magnetic moments, and response phase is governed by amplitude-dependent relaxation mechanisms, we show how and under what conditions two-tone systems become the key to independent measurement of the response from particles of different diameters. 001032533 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0 001032533 536__ $$0G:(GEPRIS)445454801$$aDFG project 445454801 - Kombinierter Feldeffekt-/Magnet-Immunsensor-Chip für den markierungsfreien Nachweise von Biomarkern (FEMIC) (445454801)$$c445454801$$x1 001032533 7001_ $$0P:(DE-Juel1)186710$$aEivazi, Faranak$$b1$$ufzj 001032533 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b2$$ufzj 001032533 7001_ $$0P:(DE-Juel1)128697$$aKrause, Hans-Joachim$$b3$$ufzj 001032533 909CO $$ooai:juser.fz-juelich.de:1032533$$pVDB 001032533 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)190282$$aForschungszentrum Jülich$$b0$$kFZJ 001032533 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)186710$$aForschungszentrum Jülich$$b1$$kFZJ 001032533 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128713$$aForschungszentrum Jülich$$b2$$kFZJ 001032533 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128697$$aForschungszentrum Jülich$$b3$$kFZJ 001032533 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0 001032533 9141_ $$y2024 001032533 920__ $$lyes 001032533 9201_ $$0I:(DE-Juel1)IBI-3-20200312$$kIBI-3$$lBioelektronik$$x0 001032533 980__ $$aconf 001032533 980__ $$aVDB 001032533 980__ $$aI:(DE-Juel1)IBI-3-20200312 001032533 980__ $$aUNRESTRICTED