%0 Journal Article
%A Wan, Bin
%A Saberi, Amin
%A Paquola, Casey
%A Schaare, H. Lina
%A Hettwer, Meike D.
%A Royer, Jessica
%A John, Alexandra
%A Dorfschmidt, Lena
%A Bayrak, Şeyma
%A Bethlehem, Richard A. I.
%A Eickhoff, Simon B.
%A Bernhardt, Boris C.
%A Valk, Sofie L.
%T Microstructural asymmetry in the human cortex
%J Nature Communications
%V 15
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M FZJ-2024-06852
%P 10124
%D 2024
%X The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 39578424
%U <Go to ISI:>//WOS:001362461900022
%R 10.1038/s41467-024-54243-9
%U https://juser.fz-juelich.de/record/1034022