001034022 001__ 1034022
001034022 005__ 20250203133229.0
001034022 0247_ $$2doi$$a10.1038/s41467-024-54243-9
001034022 0247_ $$2datacite_doi$$a10.34734/FZJ-2024-06852
001034022 0247_ $$2pmid$$a39578424
001034022 0247_ $$2WOS$$aWOS:001362461900022
001034022 037__ $$aFZJ-2024-06852
001034022 082__ $$a500
001034022 1001_ $$0P:(DE-Juel1)188407$$aWan, Bin$$b0$$eCorresponding author
001034022 245__ $$aMicrostructural asymmetry in the human cortex
001034022 260__ $$a[London]$$bNature Publishing Group UK$$c2024
001034022 3367_ $$2DRIVER$$aarticle
001034022 3367_ $$2DataCite$$aOutput Types/Journal article
001034022 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1734171650_20064
001034022 3367_ $$2BibTeX$$aARTICLE
001034022 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001034022 3367_ $$00$$2EndNote$$aJournal Article
001034022 520__ $$aThe human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance.
001034022 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001034022 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x1
001034022 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001034022 7001_ $$0P:(DE-Juel1)190448$$aSaberi, Amin$$b1
001034022 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b2$$ufzj
001034022 7001_ $$0P:(DE-Juel1)188324$$aSchaare, H. Lina$$b3
001034022 7001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D.$$b4
001034022 7001_ $$0P:(DE-HGF)0$$aRoyer, Jessica$$b5
001034022 7001_ $$0P:(DE-Juel1)200125$$aJohn, Alexandra$$b6$$ufzj
001034022 7001_ $$0P:(DE-HGF)0$$aDorfschmidt, Lena$$b7
001034022 7001_ $$0P:(DE-HGF)0$$aBayrak, Şeyma$$b8
001034022 7001_ $$0P:(DE-HGF)0$$aBethlehem, Richard A. I.$$b9
001034022 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b10$$ufzj
001034022 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b11
001034022 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b12$$eCorresponding author
001034022 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-54243-9$$gVol. 15, no. 1, p. 10124$$n1$$p10124$$tNature Communications$$v15$$x2041-1723$$y2024
001034022 8564_ $$uhttps://juser.fz-juelich.de/record/1034022/files/s41467-024-54243-9.pdf$$yOpenAccess
001034022 909CO $$ooai:juser.fz-juelich.de:1034022$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188407$$aForschungszentrum Jülich$$b0$$kFZJ
001034022 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)188407$$a Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom), Leipzig, Germany Department of Cognitive Neurology, University Hospital Leipzig and Faculty of Medicine, University of Leipzig, Leipzig, Germany Institute of Neuroscience and Medicine (INM-7: Brain and Behavior), Research Center Jülich, Jülich, Germany$$b0
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)190448$$aForschungszentrum Jülich$$b1$$kFZJ
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187055$$aForschungszentrum Jülich$$b2$$kFZJ
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188324$$aForschungszentrum Jülich$$b3$$kFZJ
001034022 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)188324$$a Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig$$b3
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187157$$aForschungszentrum Jülich$$b4$$kFZJ
001034022 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)187157$$a Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig$$b4
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)200125$$aForschungszentrum Jülich$$b6$$kFZJ
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b10$$kFZJ
001034022 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131678$$a HHU Düsseldorf$$b10
001034022 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173843$$aForschungszentrum Jülich$$b12$$kFZJ
001034022 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig$$b12
001034022 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001034022 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x1
001034022 9141_ $$y2024
001034022 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-29
001034022 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-29
001034022 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-29
001034022 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001034022 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-29
001034022 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
001034022 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-29
001034022 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2022$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-01-30T07:48:07Z
001034022 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-01-30T07:48:07Z
001034022 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2024-01-30T07:48:07Z
001034022 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-02
001034022 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2022$$d2025-01-02
001034022 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
001034022 980__ $$ajournal
001034022 980__ $$aVDB
001034022 980__ $$aUNRESTRICTED
001034022 980__ $$aI:(DE-Juel1)INM-7-20090406
001034022 9801_ $$aFullTexts