TY  - JOUR
AU  - Wan, Bin
AU  - Saberi, Amin
AU  - Paquola, Casey
AU  - Schaare, H. Lina
AU  - Hettwer, Meike D.
AU  - Royer, Jessica
AU  - John, Alexandra
AU  - Dorfschmidt, Lena
AU  - Bayrak, Şeyma
AU  - Bethlehem, Richard A. I.
AU  - Eickhoff, Simon B.
AU  - Bernhardt, Boris C.
AU  - Valk, Sofie L.
TI  - Microstructural asymmetry in the human cortex
JO  - Nature Communications
VL  - 15
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - FZJ-2024-06852
SP  - 10124
PY  - 2024
AB  - The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance.
LB  - PUB:(DE-HGF)16
C6  - 39578424
UR  - <Go to ISI:>//WOS:001362461900022
DO  - DOI:10.1038/s41467-024-54243-9
UR  - https://juser.fz-juelich.de/record/1034022
ER  -