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| 001 | 1034022 | ||
| 005 | 20250203133229.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-024-54243-9 |2 doi |
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| 100 | 1 | _ | |a Wan, Bin |0 P:(DE-Juel1)188407 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Microstructural asymmetry in the human cortex |
| 260 | _ | _ | |a [London] |c 2024 |b Nature Publishing Group UK |
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| 520 | _ | _ | |a The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across cortical layers. A similar anterior-posterior pattern is observed using in vivo Human Connectome Project (N = 1101) T1w/T2w microstructural data, with average cortical asymmetry showing the strongest similarity with post-mortem-based asymmetry of layer III. Moreover, microstructural asymmetry is found to be heritable, varies as a function of age and sex, and corresponds to intrinsic functional asymmetry. We also observe a differential association of language and markers of mental health with microstructural asymmetry patterns at the individual level, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes, possibly anchored in development. Last, we could show concordant evidence with alternative in vivo microstructural measures: magnetization transfer (N = 286) and quantitative T1 (N = 50). Together, our study highlights microstructural asymmetry in the human cortex and its functional and behavioral relevance. |
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| 700 | 1 | _ | |a Valk, Sofie L. |0 P:(DE-Juel1)173843 |b 12 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s41467-024-54243-9 |g Vol. 15, no. 1, p. 10124 |0 PERI:(DE-600)2553671-0 |n 1 |p 10124 |t Nature Communications |v 15 |y 2024 |x 2041-1723 |
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