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001034099 1001_ $$0P:(DE-HGF)0$$aKalc, Polona$$b0$$eCorresponding author
001034099 245__ $$aApproximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head
001034099 260__ $$aCambridge, MA$$bMIT Press$$c2024
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001034099 520__ $$aBones and brain are intricately connected and scientific interest in their interaction is growing. This has become particularly evident in the framework of clinical applications for various medical conditions, such as obesity and osteoporosis. The adverse effects of obesity on brain health have long been recognised, but few brain imaging studies provide sophisticated body composition measures. Here, we propose to extract the following bone- and adiposity-related measures from T1-weighted MR images of the head: an approximation of skull bone mineral density (BMD), skull bone thickness, and two approximations of subcutaneous fat (i.e., the intensity and thickness of soft non-brain head tissue). The reliability and validity of these four distinct measures were tested in two large-scale databases, the UK Biobank and OASIS-3. The measures pertaining to skull BMD, skull bone thickness, and intensity-based adiposity proxy proved to be reliable (ICC = .95/.83/.66, p < .001) and valid, with high correlations to DXA-derived head BMD values (rho = .70, p < .001) and MRI-derived abdominal subcutaneous adipose volume (rho = .62, p < .001). Thickness-based adiposity proxy had only a low retest reliability (ICC = .53, p < .001). The outcomes of this study constitute an important step towards extracting relevant non-brain features from available brain scans.
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001034099 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b1$$ufzj
001034099 7001_ $$0P:(DE-HGF)0$$aLuders, Eileen$$b2
001034099 7001_ $$0P:(DE-HGF)0$$aGaser, Christian$$b3
001034099 7001_ $$0P:(DE-HGF)0$$aDahnke, Robert$$b4
001034099 773__ $$0PERI:(DE-600)3167925-0$$a10.1162/imag_a_00390$$gVol. 2, p. 1 - 13$$p1 - 13$$tImaging neuroscience$$v2$$x2837-6056$$y2024
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001034099 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany †Corresponding Authors: Polona Kalc (polona.kalc@med.uni-jena.de)$$b0
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