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001034863 037__ $$aFZJ-2024-07610
001034863 1001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike$$b0$$eCorresponding author$$ufzj
001034863 1112_ $$aOrganization for Human Brain Mapping Conference 2024$$cSeoul$$d2024-06-24 - 2024-06-28$$wSouth Korea
001034863 245__ $$aA cortical coordinate space of psychiatric vulnerability
001034863 260__ $$c2024
001034863 3367_ $$033$$2EndNote$$aConference Paper
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001034863 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1736427532_16757$$xAfter Call
001034863 520__ $$aOverlapping psychopathological spectra may reflect an underlying, general liability for mental illness linked to shared risk factors and common alterations in neurodevelopmental processes. In three studies, we investigated how multi-scale features of brain organization shape topologically heterogeneous levels of transdiagnostic vulnerability. Combining meta-analytic cortical thickness maps of 6 major mental disorders with multi-scale data, we characterized a transdiagnostic cortical coordinate space framed by connectomic, cytoarchitectonic, and functional dimensions, along which synchronized brain alterations are organized. We identified low-dimensional cortical axes of co-alteration networks, which indicated that the likelihood of two brain regions to display synchronized illness effects, regardless of their location on the cortical landscape, is related to the degree to which these regions share cytoarchitectonic profiles and are engaged in similar functional tasks. Moreover, fronto-temporal epicenters emerged as potential connectome anchors of shared cortical alterations. We extended these observations towards symptom domains and explored a continuous coordinate space in which individuals with mental disorders are embedded based on the degree to which they express a combination of pathological brain imaging patterns – partly crossing categorical diagnoses. Last, we studied adaptation to transdiagnostic environmental risk factors during adolescence and found that adolescents’ vulnerability or resilience to environmental stressors varies during development. This intra-individual variability was tied to maturational trajectories of cortical myelination of association cortices, as well as microstructural and functional network re-organization. In my contribution, I will present multi-modal insights into brain organizational principles shaping transdiagnostic vulnerability.
001034863 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
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001034863 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187157$$aForschungszentrum Jülich$$b0$$kFZJ
001034863 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001034863 9141_ $$y2024
001034863 920__ $$lyes
001034863 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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001034863 980__ $$aVDB
001034863 980__ $$aI:(DE-Juel1)INM-7-20090406
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