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@INPROCEEDINGS{Hettwer:1034863,
      author       = {Hettwer, Meike},
      title        = {{A} cortical coordinate space of psychiatric vulnerability},
      reportid     = {FZJ-2024-07610},
      year         = {2024},
      abstract     = {Overlapping psychopathological spectra may reflect an
                      underlying, general liability for mental illness linked to
                      shared risk factors and common alterations in
                      neurodevelopmental processes. In three studies, we
                      investigated how multi-scale features of brain organization
                      shape topologically heterogeneous levels of transdiagnostic
                      vulnerability. Combining meta-analytic cortical thickness
                      maps of 6 major mental disorders with multi-scale data, we
                      characterized a transdiagnostic cortical coordinate space
                      framed by connectomic, cytoarchitectonic, and functional
                      dimensions, along which synchronized brain alterations are
                      organized. We identified low-dimensional cortical axes of
                      co-alteration networks, which indicated that the likelihood
                      of two brain regions to display synchronized illness
                      effects, regardless of their location on the cortical
                      landscape, is related to the degree to which these regions
                      share cytoarchitectonic profiles and are engaged in similar
                      functional tasks. Moreover, fronto-temporal epicenters
                      emerged as potential connectome anchors of shared cortical
                      alterations. We extended these observations towards symptom
                      domains and explored a continuous coordinate space in which
                      individuals with mental disorders are embedded based on the
                      degree to which they express a combination of pathological
                      brain imaging patterns – partly crossing categorical
                      diagnoses. Last, we studied adaptation to transdiagnostic
                      environmental risk factors during adolescence and found that
                      adolescents’ vulnerability or resilience to environmental
                      stressors varies during development. This intra-individual
                      variability was tied to maturational trajectories of
                      cortical myelination of association cortices, as well as
                      microstructural and functional network re-organization. In
                      my contribution, I will present multi-modal insights into
                      brain organizational principles shaping transdiagnostic
                      vulnerability.},
      month         = {Jun},
      date          = {2024-06-24},
      organization  = {Organization for Human Brain Mapping
                       Conference 2024, Seoul (South Korea),
                       24 Jun 2024 - 28 Jun 2024},
      subtyp        = {After Call},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1034863},
}