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001034864 037__ $$aFZJ-2024-07611
001034864 1001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike$$b0$$eCorresponding author$$ufzj
001034864 1112_ $$aPsychologie und Gehirn (PuG)$$cHamburg$$d2024-05-29 - 2024-06-01$$wGermany
001034864 245__ $$aLongitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence
001034864 260__ $$c2024
001034864 3367_ $$033$$2EndNote$$aConference Paper
001034864 3367_ $$2DataCite$$aOther
001034864 3367_ $$2BibTeX$$aINPROCEEDINGS
001034864 3367_ $$2DRIVER$$aconferenceObject
001034864 3367_ $$2ORCID$$aLECTURE_SPEECH
001034864 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1736426144_16758$$xOther
001034864 502__ $$cHeinrich-Heine-Universität Düsseldorf
001034864 520__ $$aAdolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted maturation and malleability of association cortices. Cortical malleability is shaped by myelination: It limits plasticity through consolidation and dynamically adjusts circuit efficiency. This modulatory role makes the study of myelin trajectories a compelling focus to understand the link between cortical maturation and behavioral adaptation, that is, resilience and susceptibility. Here, we investigated whether intra-individual development of adolescents’ psychosocial functioning in response to environmental adversity is linked to ongoing myeloarchitectural maturation and downstream effects on functional reorganization. We operationalized resilient outcomes as comparatively lower levels of psychosocial distress than predicted from stressor exposure (including adverse life events, family settings, and socioeconomic status). This machine learning approach provided continuous resilience scores adjusted for variations in stressor exposure at different time points. We then extracted intra-cortical myeloarchitectural profiles from myelin-sensitive imaging to capture myelination and depth-dependent trajectories of systems-level synchronization. Our findings suggest that developing towards more resilient psychosocial functioning is linked to a higher rate of prefrontal myelination alongside stabilized functional connectivity within abstract cognitive networks. Moreover, we observed stronger cortex-wide myeloarchitectural reorganization of association cortices, paralleled by attenuated functional change. Conversely, adolescents who became more susceptible to stressors exhibited maturational trajectories more closely tied to earlier stages of adolescence, as well as decreasing prefrontal connectivity. Together, trajectories of resilient psychosocial functioning link to ongoing myelin plasticity – reflected in both local growth and globally synchronized intra-cortical differentiation – and is paralleled by functional adaptation.
001034864 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001034864 7001_ $$0P:(DE-HGF)0$$aDorfschmidt, Lena$$b1
001034864 7001_ $$0P:(DE-HGF)0$$aPuhlmann, Lara$$b2
001034864 7001_ $$0P:(DE-HGF)0$$aJacob, Linda M.$$b3
001034864 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b4$$ufzj
001034864 7001_ $$0P:(DE-HGF)0$$aBethlehem, Richard A.$$b5
001034864 7001_ $$0P:(DE-HGF)0$$aBullmore, Edward T.$$b6
001034864 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b7$$ufzj
001034864 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie$$b8$$ufzj
001034864 909CO $$ooai:juser.fz-juelich.de:1034864$$pVDB
001034864 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187157$$aForschungszentrum Jülich$$b0$$kFZJ
001034864 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187055$$aForschungszentrum Jülich$$b4$$kFZJ
001034864 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b7$$kFZJ
001034864 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173843$$aForschungszentrum Jülich$$b8$$kFZJ
001034864 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001034864 9141_ $$y2024
001034864 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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001034864 980__ $$aVDB
001034864 980__ $$aI:(DE-Juel1)INM-7-20090406
001034864 980__ $$aUNRESTRICTED