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@INPROCEEDINGS{Hettwer:1034864,
      author       = {Hettwer, Meike and Dorfschmidt, Lena and Puhlmann, Lara and
                      Jacob, Linda M. and Paquola, Casey and Bethlehem, Richard A.
                      and Bullmore, Edward T. and Eickhoff, Simon and Valk, Sofie},
      title        = {{L}ongitudinal trajectories of resilient psychosocial
                      functioning link to ongoing cortical myelination and
                      functional reorganization during adolescence},
      school       = {Heinrich-Heine-Universität Düsseldorf},
      reportid     = {FZJ-2024-07611},
      year         = {2024},
      abstract     = {Adolescence is a period of dynamic brain remodeling and
                      susceptibility to psychiatric risk factors, mediated by the
                      protracted maturation and malleability of association
                      cortices. Cortical malleability is shaped by myelination: It
                      limits plasticity through consolidation and dynamically
                      adjusts circuit efficiency. This modulatory role makes the
                      study of myelin trajectories a compelling focus to
                      understand the link between cortical maturation and
                      behavioral adaptation, that is, resilience and
                      susceptibility. Here, we investigated whether
                      intra-individual development of adolescents’ psychosocial
                      functioning in response to environmental adversity is linked
                      to ongoing myeloarchitectural maturation and downstream
                      effects on functional reorganization. We operationalized
                      resilient outcomes as comparatively lower levels of
                      psychosocial distress than predicted from stressor exposure
                      (including adverse life events, family settings, and
                      socioeconomic status). This machine learning approach
                      provided continuous resilience scores adjusted for
                      variations in stressor exposure at different time points. We
                      then extracted intra-cortical myeloarchitectural profiles
                      from myelin-sensitive imaging to capture myelination and
                      depth-dependent trajectories of systems-level
                      synchronization. Our findings suggest that developing
                      towards more resilient psychosocial functioning is linked to
                      a higher rate of prefrontal myelination alongside stabilized
                      functional connectivity within abstract cognitive networks.
                      Moreover, we observed stronger cortex-wide
                      myeloarchitectural reorganization of association cortices,
                      paralleled by attenuated functional change. Conversely,
                      adolescents who became more susceptible to stressors
                      exhibited maturational trajectories more closely tied to
                      earlier stages of adolescence, as well as decreasing
                      prefrontal connectivity. Together, trajectories of resilient
                      psychosocial functioning link to ongoing myelin plasticity
                      – reflected in both local growth and globally synchronized
                      intra-cortical differentiation – and is paralleled by
                      functional adaptation.},
      month         = {May},
      date          = {2024-05-29},
      organization  = {Psychologie und Gehirn (PuG), Hamburg
                       (Germany), 29 May 2024 - 1 Jun 2024},
      subtyp        = {Other},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1034864},
}