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| Home > Publications database > Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence > print |
| 001 | 1034864 | ||
| 005 | 20250203103406.0 | ||
| 037 | _ | _ | |a FZJ-2024-07611 |
| 100 | 1 | _ | |a Hettwer, Meike |0 P:(DE-Juel1)187157 |b 0 |e Corresponding author |u fzj |
| 111 | 2 | _ | |a Psychologie und Gehirn (PuG) |c Hamburg |d 2024-05-29 - 2024-06-01 |w Germany |
| 245 | _ | _ | |a Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence |
| 260 | _ | _ | |c 2024 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
| 336 | 7 | _ | |a Other |2 DataCite |
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| 336 | 7 | _ | |a Conference Presentation |b conf |m conf |0 PUB:(DE-HGF)6 |s 1736426144_16758 |2 PUB:(DE-HGF) |x Other |
| 502 | _ | _ | |c Heinrich-Heine-Universität Düsseldorf |
| 520 | _ | _ | |a Adolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted maturation and malleability of association cortices. Cortical malleability is shaped by myelination: It limits plasticity through consolidation and dynamically adjusts circuit efficiency. This modulatory role makes the study of myelin trajectories a compelling focus to understand the link between cortical maturation and behavioral adaptation, that is, resilience and susceptibility. Here, we investigated whether intra-individual development of adolescents’ psychosocial functioning in response to environmental adversity is linked to ongoing myeloarchitectural maturation and downstream effects on functional reorganization. We operationalized resilient outcomes as comparatively lower levels of psychosocial distress than predicted from stressor exposure (including adverse life events, family settings, and socioeconomic status). This machine learning approach provided continuous resilience scores adjusted for variations in stressor exposure at different time points. We then extracted intra-cortical myeloarchitectural profiles from myelin-sensitive imaging to capture myelination and depth-dependent trajectories of systems-level synchronization. Our findings suggest that developing towards more resilient psychosocial functioning is linked to a higher rate of prefrontal myelination alongside stabilized functional connectivity within abstract cognitive networks. Moreover, we observed stronger cortex-wide myeloarchitectural reorganization of association cortices, paralleled by attenuated functional change. Conversely, adolescents who became more susceptible to stressors exhibited maturational trajectories more closely tied to earlier stages of adolescence, as well as decreasing prefrontal connectivity. Together, trajectories of resilient psychosocial functioning link to ongoing myelin plasticity – reflected in both local growth and globally synchronized intra-cortical differentiation – and is paralleled by functional adaptation. |
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| 700 | 1 | _ | |a Dorfschmidt, Lena |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Puhlmann, Lara |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Jacob, Linda M. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Paquola, Casey |0 P:(DE-Juel1)187055 |b 4 |u fzj |
| 700 | 1 | _ | |a Bethlehem, Richard A. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Bullmore, Edward T. |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Eickhoff, Simon |0 P:(DE-Juel1)131678 |b 7 |u fzj |
| 700 | 1 | _ | |a Valk, Sofie |0 P:(DE-Juel1)173843 |b 8 |u fzj |
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