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@ARTICLE{Melnikov:1035128,
      author       = {Melnikov, Nataly and Junglas, Benedikt and Halbi, Gal and
                      Nachmias, Dikla and Zerbib, Erez and Gueta, Noam and Upcher,
                      Alexander and Zalk, Ran and Sachse, Carsten and
                      Bernheim-Groswasser, Anne and Elia, Natalie},
      title        = {{T}he {A}sgard archaeal {ESCRT}-{III} system forms helical
                      filaments and remodels eukaryotic-like membranes},
      journal      = {The EMBO journal},
      volume       = {44},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2025-00217},
      pages        = {665-681},
      year         = {2025},
      abstract     = {The ESCRT machinery mediates membrane remodeling in
                      numerous processes in cells including cell division and
                      nuclear membrane reformation. The identification of ESCRT
                      homologs in Asgardarchaea, currently considered the closest
                      prokaryotic relative of eukaryotes, implies a role for
                      ESCRTs in the membrane remodeling processes that occurred
                      during eukaryogenesis. Yet, the function of these distant
                      ESCRT homologs is mostly unresolved. Here we show that
                      Asgard ESCRT-III proteins of the Lokiarcheota self-assemble
                      into helical filaments, a hallmark of the ESCRT system. We
                      determined the cryo-EM structure of the filaments at 3.6
                      Å resolution and found that they share features of
                      bacterial and eukaryotic ESCRT-III assemblies. Markedly,
                      Asgard ESCRT-III filaments bound and deformed
                      eukaryotic-like membrane vesicles. Oligonucleotides
                      facilitated the assembly of ESCRT-III filaments and tuned
                      the extent of membrane remodeling. The ability of Asgard
                      archaeal ESCRTs to remodel eukaryotic-like membranes, which
                      are fundamentally different from archaeal membranes, and the
                      structural properties of these proteins places them at the
                      junction between prokaryotes and eukaryotes.},
      cin          = {ER-C-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39753954},
      UT           = {WOS:001388934600001},
      doi          = {10.1038/s44318-024-00346-4},
      url          = {https://juser.fz-juelich.de/record/1035128},
}