guest ::
| Home > Publications database > The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes > print |
| Home > Publications database > The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes > print |
| 001 | 1035128 | ||
| 005 | 20250310131241.0 | ||
| 024 | 7 | _ | |a 10.1038/s44318-024-00346-4 |2 doi |
| 024 | 7 | _ | |a 0261-4189 |2 ISSN |
| 024 | 7 | _ | |a 1460-2075 |2 ISSN |
| 024 | 7 | _ | |a 10.34734/FZJ-2025-00217 |2 datacite_doi |
| 024 | 7 | _ | |a 39753954 |2 pmid |
| 024 | 7 | _ | |a WOS:001388934600001 |2 WOS |
| 037 | _ | _ | |a FZJ-2025-00217 |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Melnikov, Nataly |0 0000-0002-8545-8963 |b 0 |
| 245 | _ | _ | |a The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2025 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1740132060_12350 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgardarchaea, currently considered the closest prokaryotic relative of eukaryotes, implies a role for ESCRTs in the membrane remodeling processes that occurred during eukaryogenesis. Yet, the function of these distant ESCRT homologs is mostly unresolved. Here we show that Asgard ESCRT-III proteins of the Lokiarcheota self-assemble into helical filaments, a hallmark of the ESCRT system. We determined the cryo-EM structure of the filaments at 3.6 Å resolution and found that they share features of bacterial and eukaryotic ESCRT-III assemblies. Markedly, Asgard ESCRT-III filaments bound and deformed eukaryotic-like membrane vesicles. Oligonucleotides facilitated the assembly of ESCRT-III filaments and tuned the extent of membrane remodeling. The ability of Asgard archaeal ESCRTs to remodel eukaryotic-like membranes, which are fundamentally different from archaeal membranes, and the structural properties of these proteins places them at the junction between prokaryotes and eukaryotes. |
| 536 | _ | _ | |a 5352 - Understanding the Functionality of Soft Matter and Biomolecular Systems (POF4-535) |0 G:(DE-HGF)POF4-5352 |c POF4-535 |f POF IV |x 0 |
| 536 | _ | _ | |a 5241 - Molecular Information Processing in Cellular Systems (POF4-524) |0 G:(DE-HGF)POF4-5241 |c POF4-524 |f POF IV |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Junglas, Benedikt |0 P:(DE-Juel1)181012 |b 1 |
| 700 | 1 | _ | |a Halbi, Gal |b 2 |
| 700 | 1 | _ | |a Nachmias, Dikla |0 0000-0003-4154-7136 |b 3 |
| 700 | 1 | _ | |a Zerbib, Erez |0 0000-0003-2626-0532 |b 4 |
| 700 | 1 | _ | |a Gueta, Noam |0 0009-0004-0847-2667 |b 5 |
| 700 | 1 | _ | |a Upcher, Alexander |0 0000-0002-0910-6552 |b 6 |
| 700 | 1 | _ | |a Zalk, Ran |0 0000-0003-4251-6497 |b 7 |
| 700 | 1 | _ | |a Sachse, Carsten |0 P:(DE-Juel1)173949 |b 8 |e Corresponding author |
| 700 | 1 | _ | |a Bernheim-Groswasser, Anne |0 0000-0003-3999-6098 |b 9 |
| 700 | 1 | _ | |a Elia, Natalie |0 0000-0002-2537-6173 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1038/s44318-024-00346-4 |0 PERI:(DE-600)1467419-1 |p 665-681 |t The EMBO journal |v 44 |y 2025 |x 0261-4189 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1035128/files/melnikov-et-al-2025-the-asgard-archaeal-escrt-iii-system-forms-helical-filaments-and-remodels-eukaryotic-like-membranes.pdf |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:1035128 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)181012 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 8 |6 P:(DE-Juel1)173949 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Materials Systems Engineering |1 G:(DE-HGF)POF4-530 |0 G:(DE-HGF)POF4-535 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Materials Information Discovery |9 G:(DE-HGF)POF4-5352 |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-524 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Molecular and Cellular Information Processing |9 G:(DE-HGF)POF4-5241 |x 1 |
| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2023-08-24 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b EMBO J : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b EMBO J : 2022 |d 2023-08-24 |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2023-08-24 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2023-08-24 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2023-08-24 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2023-08-24 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)ER-C-3-20170113 |k ER-C-3 |l Strukturbiologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)ER-C-3-20170113 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|