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001035148 1001_ $$0P:(DE-Juel1)177730$$aBlömeke, Lara$$b0
001035148 245__ $$aBlood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
001035148 260__ $$a[London]$$bSpringer Nature$$c2024
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001035148 520__ $$aBackground: Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and selective technology because of very low Aβ oligomer concentrations and possible interference from matrix components.Methods: In this report, we developed and validated a surface-based fluorescence distribution analysis (sFIDA) assay for quantification of Aβ oligomers in plasma.Results: The blood-based sFIDA assay delivers a sensitivity of 1.8 fM, an inter- and intra-assay variation below 20% for oligomer calibration standards and no interference with matrix components. Quantification of Aβ oligomers in 359 plasma samples from the DELCODE cohort reveals lower oligomer concentrations in subjective cognitive decline and AD patients than healthy Control participants.Conclusions: Correlation analysis between CSF and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on the ApoE ε4 status.
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001035148 7001_ $$0P:(DE-Juel1)190725$$aRehn, Fabian$$b1
001035148 7001_ $$0P:(DE-Juel1)171619$$aPils, Marlene$$b2
001035148 7001_ $$0P:(DE-Juel1)172001$$aKraemer-Schulien, Victoria$$b3
001035148 7001_ $$0P:(DE-Juel1)139572$$aCousin, Anneliese$$b4$$ufzj
001035148 7001_ $$0P:(DE-Juel1)159137$$aKutzsche, Janine$$b5
001035148 7001_ $$0P:(DE-Juel1)162212$$aBujnicki, Tuyen$$b6
001035148 7001_ $$00000-0002-2141-8671$$aFreiesleben, Silka D.$$b7
001035148 7001_ $$00000-0001-5822-1744$$aSchneider, Luisa-Sophie$$b8
001035148 7001_ $$0P:(DE-HGF)0$$aPreis, Lukas$$b9
001035148 7001_ $$0P:(DE-HGF)0$$aPriller, Josef$$b10
001035148 7001_ $$0P:(DE-HGF)0$$aSpruth, Eike J.$$b11
001035148 7001_ $$0P:(DE-HGF)0$$aAltenstein, Slawek$$b12
001035148 7001_ $$00000-0001-9540-8700$$aSchneider, Anja$$b13
001035148 7001_ $$0P:(DE-HGF)0$$aFliessbach, Klaus$$b14
001035148 7001_ $$00000-0003-1492-5330$$aWiltfang, Jens$$b15
001035148 7001_ $$00000-0001-5785-9594$$aHansen, Niels$$b16
001035148 7001_ $$0P:(DE-HGF)0$$aRostamzadeh, Ayda$$b17
001035148 7001_ $$0P:(DE-HGF)0$$aDüzel, Emrah$$b18
001035148 7001_ $$0P:(DE-HGF)0$$aGlanz, Wenzel$$b19
001035148 7001_ $$00000-0003-2014-4098$$aIncesoy, Enise I.$$b20
001035148 7001_ $$0P:(DE-HGF)0$$aBuerger, Katharina$$b21
001035148 7001_ $$0P:(DE-HGF)0$$aJanowitz, Daniel$$b22
001035148 7001_ $$0P:(DE-HGF)0$$aEwers, Michael$$b23
001035148 7001_ $$0P:(DE-HGF)0$$aPerneczky, Robert$$b24
001035148 7001_ $$0P:(DE-HGF)0$$aRauchmann, Boris-Stephan$$b25
001035148 7001_ $$0P:(DE-HGF)0$$aTeipel, Stefan$$b26
001035148 7001_ $$0P:(DE-HGF)0$$aKilimann, Ingo$$b27
001035148 7001_ $$0P:(DE-HGF)0$$aLaske, Christoph$$b28
001035148 7001_ $$0P:(DE-HGF)0$$aMunk, Matthias H.$$b29
001035148 7001_ $$0P:(DE-HGF)0$$aSpottke, Annika$$b30
001035148 7001_ $$0P:(DE-HGF)0$$aRoy, Nina$$b31
001035148 7001_ $$00000-0003-4996-1630$$aHeneka, Michael T.$$b32
001035148 7001_ $$00000-0003-3137-7516$$aBrosseron, Frederic$$b33
001035148 7001_ $$aWagner, Michael$$b34
001035148 7001_ $$0P:(DE-HGF)0$$aRoeske, Sandra$$b35
001035148 7001_ $$00000-0003-4991-763X$$aRamirez, Alfredo$$b36
001035148 7001_ $$0P:(DE-HGF)0$$aSchmid, Matthias$$b37
001035148 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b38
001035148 7001_ $$0P:(DE-Juel1)157832$$aBannach, Oliver$$b39$$ufzj
001035148 7001_ $$0P:(DE-Juel1)161184$$aPeters, Oliver$$b40
001035148 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b41$$eCorresponding author
001035148 773__ $$0PERI:(DE-600)3096949-9$$a10.1038/s43856-024-00690-w$$gVol. 4, no. 1, p. 262$$n1$$p262$$tCommunications medicine$$v4$$x2730-664X$$y2024
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