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@ARTICLE{Blmeke:1035148,
      author       = {Blömeke, Lara and Rehn, Fabian and Pils, Marlene and
                      Kraemer-Schulien, Victoria and Cousin, Anneliese and
                      Kutzsche, Janine and Bujnicki, Tuyen and Freiesleben, Silka
                      D. and Schneider, Luisa-Sophie and Preis, Lukas and Priller,
                      Josef and Spruth, Eike J. and Altenstein, Slawek and
                      Schneider, Anja and Fliessbach, Klaus and Wiltfang, Jens and
                      Hansen, Niels and Rostamzadeh, Ayda and Düzel, Emrah and
                      Glanz, Wenzel and Incesoy, Enise I. and Buerger, Katharina
                      and Janowitz, Daniel and Ewers, Michael and Perneczky,
                      Robert and Rauchmann, Boris-Stephan and Teipel, Stefan and
                      Kilimann, Ingo and Laske, Christoph and Munk, Matthias H.
                      and Spottke, Annika and Roy, Nina and Heneka, Michael T. and
                      Brosseron, Frederic and Wagner, Michael and Roeske, Sandra
                      and Ramirez, Alfredo and Schmid, Matthias and Jessen, Frank
                      and Bannach, Oliver and Peters, Oliver and Willbold, Dieter},
      title        = {{B}lood-based quantification of {A}β oligomers indicates
                      impaired clearance from brain in {A}po{E} ε4 positive
                      subjects},
      journal      = {Communications medicine},
      volume       = {4},
      number       = {1},
      issn         = {2730-664X},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-00235},
      pages        = {262},
      year         = {2024},
      abstract     = {Background: Quantification of Amyloid beta (Aβ) oligomers
                      in plasma enables early diagnosis of Alzheimer's Disease
                      (AD) and improves our understanding of underlying
                      pathologies. However, quantification necessitates an
                      extremely sensitive and selective technology because of very
                      low Aβ oligomer concentrations and possible interference
                      from matrix components.Methods: In this report, we developed
                      and validated a surface-based fluorescence distribution
                      analysis (sFIDA) assay for quantification of Aβ oligomers
                      in plasma.Results: The blood-based sFIDA assay delivers a
                      sensitivity of 1.8 fM, an inter- and intra-assay variation
                      below $20\%$ for oligomer calibration standards and no
                      interference with matrix components. Quantification of Aβ
                      oligomers in 359 plasma samples from the DELCODE cohort
                      reveals lower oligomer concentrations in subjective
                      cognitive decline and AD patients than healthy Control
                      participants.Conclusions: Correlation analysis between CSF
                      and plasma oligomer concentrations indicates an impaired
                      clearance of Aβ oligomers that is dependent on the ApoE ε4
                      status.},
      cin          = {IBI-7},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39658587},
      UT           = {WOS:001374151500001},
      doi          = {10.1038/s43856-024-00690-w},
      url          = {https://juser.fz-juelich.de/record/1035148},
}