% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Krapf:1035303,
      author       = {Krapf, Philipp and Wicher, Thomas and Zlatopolskiy, Boris
                      and Ermert, Johannes and Neumaier, Bernd},
      title        = {{F}ully automated production of
                      ((({S})-1-carboxy-5-(6-([18{F}]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic
                      acid ([18{F}]{JKPSMA}-7},
      journal      = {Pharmaceuticals},
      volume       = {18},
      number       = {1},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2025-00361},
      pages        = {119 -},
      year         = {2025},
      abstract     = {The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging
                      agent for positron emission tomography (PET), was previously
                      synthesized by indirect radiofluorination using an
                      18F-labeled active ester as a prosthetic group, which had to
                      be isolated and purified before it could be linked to the
                      pharmacologically active Lys-urea-Glu motif. Although this
                      procedure could be automated on two-reactor modules like the
                      GE TRACERLab FX2N (FXN) to afford the tracer in modest
                      radiochemical yields (RCY) of $18–25\%,$ it is unsuitable
                      for cassette-based systems with a single reactor. Methods:
                      To simplify implementation on an automated synthesis module,
                      the radiosynthesis of [18F]JK-PSMA-7 was devised as a
                      one-pot, two-step reaction. The new method is based on
                      direct (“late-stage”) radiofluorination of an
                      appropriate onium triflate precursor and subsequent
                      deprotection with ortho-phosphoric acid. It was successfully
                      established on the cassette-based Trasis AllInOne (AIO)
                      module. Results: Overall, the new protocol enabled the
                      production of [18F]JK-PSMA-7 in activity yields of 39 ±
                      $4\%(RCY$ = $58\%)$ with an overall synthesis time of about
                      1 h. In a single production run with an initial activity of
                      36-43 GBq, 13-19 GBq of [18F]JK-PSMA-7 with a radiochemical
                      purity of $>99\%was$ obtained. Conclusions: We have
                      established a highly reliable, GMP-compliant process for the
                      automated radiosynthesis of [18F]JK-PSMA-7 on the Trasis
                      AllinOne (AIO) synthesizer, ensuring consistent and
                      efficient production of this radioligand.},
      cin          = {INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39861180},
      UT           = {WOS:001405742900001},
      doi          = {10.3390/ph18010119},
      url          = {https://juser.fz-juelich.de/record/1035303},
}