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@ARTICLE{Bukhdruker:1037173,
      author       = {Bukhdruker, S. and Melnikov, I. and Baeken, C. and
                      Balandin, T. and Gordeliy, V.},
      title        = {{C}rystallographic insights into lipid-membrane protein
                      interactions in microbial rhodopsins},
      journal      = {Frontiers in molecular biosciences},
      volume       = {11},
      issn         = {2296-889X},
      address      = {Lausanne},
      publisher    = {Frontiers},
      reportid     = {FZJ-2025-00518},
      pages        = {1503709},
      year         = {2024},
      abstract     = {The primary goal of our work is to provide structural
                      insights into the influence of the hydrophobic lipid
                      environment on the membrane proteins (MPs) structure and
                      function. Our work will not cover the well-studied
                      hydrophobic mismatch between the lipid bilayer and MPs.
                      Instead, we will focus on the lessstudied direct molecular
                      interactions of lipids with the hydrophobic surfaces of MPs.
                      To visualize the first layer of amphiphiles surrounding MPs
                      and analyze their interaction with the proteins, we use the
                      available highest-quality crystallographic structures of
                      microbial rhodopsins. The results of the structurebased
                      analysis allowed us to formulate the hypothetical concept of
                      the role of the nearest layer of the lipids as an integral
                      part of the MPs that are important for their structure and
                      function. We then discuss how the lipid-MPs interaction is
                      influenced by exogenous hydrophobic molecules, noble gases,
                      which can compete with lipids for the surface of MPs and can
                      be used in the systematic approach to verify the proposed
                      concept experimentally. Finally, we raise the problems of
                      currently available structural data that should be overcome
                      to obtain a more profound picture of the lipid-MP
                      interactions.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {39606035},
      UT           = {WOS:001363684300001},
      doi          = {10.3389/fmolb.2024.1503709},
      url          = {https://juser.fz-juelich.de/record/1037173},
}