%0 Journal Article
%A Baldermann, Juan Carlos
%A Petry-Schmelzer, Jan Niklas
%A Schüller, Thomas
%A Mahfoud, Lin
%A Brandt, Gregor A.
%A Dembek, Till A.
%A van der Linden, Christina
%A Krauss, Joachim K.
%A Szejko, Natalia
%A Müller-Vahl, Kirsten R.
%A Ganos, Christos
%A Al-Fatly, Bassam
%A Heiden, Petra
%A Servello, Domenico
%A Galbiati, Tommaso
%A Johnson, Kara A.
%A Butson, Christopher R.
%A Okun, Michael S.
%A Andrade, Pablo
%A Domschke, Katharina
%A Fink, Gereon Rudolf
%A Fox, Michael D.
%A Horn, Andreas
%A Kuhn, Jens
%A Visser-Vandewalle, Veerle
%A Barbe, Michael T.
%T A critical role of action-related functional networks in Gilles de la Tourette syndrome
%J Nature Communications
%V 15
%N 1
%@ 2041-1723
%C [London]
%I Springer Nature
%M FZJ-2025-00564
%P 10687
%D 2024
%Z Open Access funding enabled and organized by Projekt DEAL.This study was funded by the German Research Foundation (CRC-1451,Project 431549029-C07, to J.C.B. and V.V.V.) and the Else Kröner-Fresenius-Stiftung (grant number 2022_EKES.23 to J.C.B.). A.H. wassupported by the German Research Foundation (Deutsche Forschungsgemeinschaft, 424778381 – TRR 295), Deutsches Zentrum für Luft- undRaumfahrt (DynaSti grant within the EU Joint Programme NeurodegenerativeDisease Research, JPND), the National Institutes of Health (R0113478451, 1R01NS127892-01, 2R01 MH113929 & UM1NS132358), and theNew Venture Fund (FFOR Seed Grant). JNPS was funded by the CologneClinician Scientist Program (CCSP) / Faculty of Medicine / University ofCologne, funded by theGerman Research Foundation (DFG, FI 773/15-1).
%X Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 39681552
%U <Go to ISI:>//WOS:001379684000003
%R 10.1038/s41467-024-55242-6
%U https://juser.fz-juelich.de/record/1037231