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001037231 1001_ $$0P:(DE-HGF)0$$aBaldermann, Juan Carlos$$b0$$eCorresponding author
001037231 245__ $$aA critical role of action-related functional networks in Gilles de la Tourette syndrome
001037231 260__ $$a[London]$$bSpringer Nature$$c2024
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001037231 500__ $$aOpen Access funding enabled and organized by Projekt DEAL.This study was funded by the German Research Foundation (CRC-1451,Project 431549029-C07, to J.C.B. and V.V.V.) and the Else Kröner-Fresenius-Stiftung (grant number 2022_EKES.23 to J.C.B.). A.H. wassupported by the German Research Foundation (Deutsche Forschungsgemeinschaft, 424778381 – TRR 295), Deutsches Zentrum für Luft- undRaumfahrt (DynaSti grant within the EU Joint Programme NeurodegenerativeDisease Research, JPND), the National Institutes of Health (R0113478451, 1R01NS127892-01, 2R01 MH113929 & UM1NS132358), and theNew Venture Fund (FFOR Seed Grant). JNPS was funded by the CologneClinician Scientist Program (CCSP) / Faculty of Medicine / University ofCologne, funded by theGerman Research Foundation (DFG, FI 773/15-1).
001037231 520__ $$aGilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS.
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001037231 536__ $$0G:(GEPRIS)458687122$$aSFB 1451 C07 - Neuronale Grundlagen der Bildung und Unterdrückung motorischer Tics (C07) (458687122)$$c458687122$$x1
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001037231 7001_ $$0P:(DE-HGF)0$$aPetry-Schmelzer, Jan Niklas$$b1
001037231 7001_ $$00000-0003-1232-7871$$aSchüller, Thomas$$b2
001037231 7001_ $$0P:(DE-HGF)0$$aMahfoud, Lin$$b3
001037231 7001_ $$00000-0002-9984-2069$$aBrandt, Gregor A.$$b4
001037231 7001_ $$0P:(DE-HGF)0$$aDembek, Till A.$$b5
001037231 7001_ $$00000-0003-2091-4638$$avan der Linden, Christina$$b6
001037231 7001_ $$00000-0002-0675-9064$$aKrauss, Joachim K.$$b7
001037231 7001_ $$0P:(DE-HGF)0$$aSzejko, Natalia$$b8
001037231 7001_ $$00000-0002-7181-7419$$aMüller-Vahl, Kirsten R.$$b9
001037231 7001_ $$0P:(DE-HGF)0$$aGanos, Christos$$b10
001037231 7001_ $$00000-0003-0067-6177$$aAl-Fatly, Bassam$$b11
001037231 7001_ $$0P:(DE-HGF)0$$aHeiden, Petra$$b12
001037231 7001_ $$0P:(DE-HGF)0$$aServello, Domenico$$b13
001037231 7001_ $$00000-0003-1950-1633$$aGalbiati, Tommaso$$b14
001037231 7001_ $$00000-0001-6556-8957$$aJohnson, Kara A.$$b15
001037231 7001_ $$0P:(DE-HGF)0$$aButson, Christopher R.$$b16
001037231 7001_ $$00000-0002-6247-9358$$aOkun, Michael S.$$b17
001037231 7001_ $$0P:(DE-HGF)0$$aAndrade, Pablo$$b18
001037231 7001_ $$00000-0002-2550-9132$$aDomschke, Katharina$$b19
001037231 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b20$$ufzj
001037231 7001_ $$00000-0001-8848-6399$$aFox, Michael D.$$b21
001037231 7001_ $$00000-0002-0695-6025$$aHorn, Andreas$$b22
001037231 7001_ $$00000-0002-4719-5293$$aKuhn, Jens$$b23
001037231 7001_ $$00000-0002-5274-7929$$aVisser-Vandewalle, Veerle$$b24
001037231 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b25
001037231 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-55242-6$$gVol. 15, no. 1, p. 10687$$n1$$p10687$$tNature Communications$$v15$$x2041-1723$$y2024
001037231 8564_ $$uNat Commun  . 2024 Dec 16;15(1):10687.
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