TY  - JOUR
AU  - Baldermann, Juan Carlos
AU  - Petry-Schmelzer, Jan Niklas
AU  - Schüller, Thomas
AU  - Mahfoud, Lin
AU  - Brandt, Gregor A.
AU  - Dembek, Till A.
AU  - van der Linden, Christina
AU  - Krauss, Joachim K.
AU  - Szejko, Natalia
AU  - Müller-Vahl, Kirsten R.
AU  - Ganos, Christos
AU  - Al-Fatly, Bassam
AU  - Heiden, Petra
AU  - Servello, Domenico
AU  - Galbiati, Tommaso
AU  - Johnson, Kara A.
AU  - Butson, Christopher R.
AU  - Okun, Michael S.
AU  - Andrade, Pablo
AU  - Domschke, Katharina
AU  - Fink, Gereon Rudolf
AU  - Fox, Michael D.
AU  - Horn, Andreas
AU  - Kuhn, Jens
AU  - Visser-Vandewalle, Veerle
AU  - Barbe, Michael T.
TI  - A critical role of action-related functional networks in Gilles de la Tourette syndrome
JO  - Nature Communications
VL  - 15
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - FZJ-2025-00564
SP  - 10687
PY  - 2024
N1  - Open Access funding enabled and organized by Projekt DEAL.This study was funded by the German Research Foundation (CRC-1451,Project 431549029-C07, to J.C.B. and V.V.V.) and the Else Kröner-Fresenius-Stiftung (grant number 2022_EKES.23 to J.C.B.). A.H. wassupported by the German Research Foundation (Deutsche Forschungsgemeinschaft, 424778381 – TRR 295), Deutsches Zentrum für Luft- undRaumfahrt (DynaSti grant within the EU Joint Programme NeurodegenerativeDisease Research, JPND), the National Institutes of Health (R0113478451, 1R01NS127892-01, 2R01 MH113929 & UM1NS132358), and theNew Venture Fund (FFOR Seed Grant). JNPS was funded by the CologneClinician Scientist Program (CCSP) / Faculty of Medicine / University ofCologne, funded by theGerman Research Foundation (DFG, FI 773/15-1).
AB  - Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants. We find that greater tic reduction is linked to higher connectivity of DBS sites (N = 37) with action-related functional resting-state networks, i.e., the cingulo-opercular (r = 0.62; p < 0.001) and somato-cognitive action networks (r = 0.47; p = 0.002). Regions of the cingulo-opercular network best match the optimal connectivity profiles of thalamic DBS. We replicate the significance of targeting cingulo-opercular and somato-cognitive action network connectivity in an independent DBS cohort (N = 10). Finally, we demonstrate that tic-inducing brain lesions (N = 22) exhibit similar connectivity to these networks. Collectively, these results suggest a critical role for these action-related networks in the pathophysiology and treatment of GTS.
LB  - PUB:(DE-HGF)16
C6  - 39681552
UR  - <Go to ISI:>//WOS:001379684000003
DO  - DOI:10.1038/s41467-024-55242-6
UR  - https://juser.fz-juelich.de/record/1037231
ER  -